HitPredict

Interactor 1: CXCL7 (P02775)
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Gene: PPBP

Interactor 2: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0071222 - cellular response to lipopolysaccharide GO:1904724 - tertiary granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 707
+	Hs
		540419 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		540414 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		540420 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		486175 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		364043 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		364034 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Mm
		714630 CXCL5_MOUSE (1-127): 1.33e-40: 133: 39.37		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Hs
		764724 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		587770 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		372733 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		372731 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Mm
		500671 CXCL2_MOUSE (51-127): 2.03e-29: 104: 49.35		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Hs
		587787 CXCL3_HUMAN (57-127): 1.67e-26: 96.7: 50.70		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		764727 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		448989 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		MMP12_HUMAN (7-274): 1.14e-87: 284: 31.47
+	Hs
		372737 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Mm
		714631 CXCL3_MOUSE (51-127): 1.23e-27: 99.4: 42.86		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Mm
		522396 GROA_MOUSE (53-123): 1.4e-27: 99: 59.16		MMP12_MOUSE (6-248): 1.03e-84: 277: 32.95
+	Hs
		372724 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		612139 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		MMP8_HUMAN (35-295): 3.17e-81: 267: 32.01