HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 2752
+	Hs
		64820 EGFR_HUMAN (1-1210): 0: 1246: 100.00		F186A_HUMAN (1006-2741): 2.63e-76: 286: 9.64
+	Hs
		363144 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ANK2_HUMAN (891-2752): 1.07e-73: 278: 9.65
+	Hs
		362705 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC1_HUMAN (1729-2752): 1.62e-47: 190: 14.56
+	Hs
		363641 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TITIN_HUMAN (806-2717): 2.01e-34: 148: 6.33
+	Hs
		363843 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TARA_HUMAN (1786-2752): 7.08e-22: 107: 11.78
+	Hs
		363637 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC16_HUMAN (1412-2752): 7.11e-21: 103: 10.86
+	Hs
		590283 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		MUC1_HUMAN (1729-2752): 1.62e-47: 190: 14.56
+	Hs
		363752 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC4_HUMAN (1826-2752): 5.49e-17: 90.9: 12.06
+	Hs
		363748 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MINT_HUMAN (1037-2739): 1.99e-14: 82.5: 7.35
+	Hs
		410586 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC1_HUMAN (1729-2752): 1.62e-47: 190: 14.56
+	Hs
		590242 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		MUC1_HUMAN (1729-2752): 1.62e-47: 190: 14.56
+	Hs
		1145772 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		MUC4_HUMAN (1826-2752): 5.49e-17: 90.9: 12.06
+	Hs
		411016 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC4_HUMAN (1826-2752): 5.49e-17: 90.9: 12.06
+	Hs
		641661 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		MUC4_HUMAN (1826-2752): 5.49e-17: 90.9: 12.06
+	Hs
		1051084 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		SRRM2_HUMAN (1-2752): 2.19e-171: 594: 100.00
+	Hs
		710812 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		ANK2_HUMAN (891-2752): 1.07e-73: 278: 9.65
+	Hs
		334271 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		TACC2_HUMAN (1528-2749): 8.32e-16: 87.1: 8.92
+	Hs
		710482 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		TARA_HUMAN (1786-2752): 7.08e-22: 107: 11.78
+	Mm
		1041412 EPHA4_MOUSE (660-1069): 1.99e-122: 404: 28.27		NCOR2_MOUSE (161-1367): 5.56e-13: 77.4: 9.23
+	Mm
		236925 ACK1_MOUSE (691-967): 2.41e-53: 206: 38.87		ANK2_MOUSE (875-2680): 3e-20: 101: 14.69