HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Method score

Annotation score

Interaction score

0.95

1.00

0.975

Property	Details
Experiments	27703006, 28806393, 28205554, 31980649, 36244648, 38496616, 16093354, 15925322, 20130576, 17979178, 22169110, 22510884
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology, in-gel kinase assay, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, phosphorylation reaction, association

Property

Details

Experiments

27703006, 28806393, 28205554, 31980649, 36244648, 38496616, 16093354, 15925322, 20130576, 17979178, 22169110, 22510884

Identification Methods

affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology, in-gel kinase assay, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification

Interaction Type

physical association, direct interaction, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	C1_1~C1_1, C1_1~Pkinase, C1_1~RBD, Pkinase~Pkinase, RBD~RBD
Common GO terms	GO:0000165 - MAPK cascade GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity GO:0004709 - MAP kinase kinase kinase activity GO:0005524 - ATP binding and 46 others more... GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0007190 - activation of adenylate cyclase activity GO:0007265 - Ras protein signal transduction GO:0008285 - negative regulation of cell population proliferation GO:0008286 - insulin receptor signaling pathway GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0014044 - Schwann cell development GO:0019899 - enzyme binding GO:0030878 - thyroid gland development GO:0031143 - pseudopodium GO:0031333 - negative regulation of protein-containing complex assembly GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0035019 - somatic stem cell population maintenance GO:0035023 - regulation of Rho protein signal transduction GO:0035773 - insulin secretion involved in cellular response to glucose stimulus GO:0035994 - response to muscle stretch GO:0038133 - ERBB2-ERBB3 signaling pathway GO:0042060 - wound healing GO:0042552 - myelination GO:0042981 - regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043154 - negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043410 - positive regulation of MAPK cascade GO:0044342 - type B pancreatic cell proliferation GO:0045104 - intermediate filament cytoskeleton organization GO:0045595 - regulation of cell differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding GO:0048009 - insulin-like growth factor receptor signaling pathway GO:0048011 - neurotrophin TRK receptor signaling pathway GO:0048538 - thymus development GO:0060324 - face development GO:0060333 - type II interferon-mediated signaling pathway GO:0071550 - death-inducing signaling complex assembly GO:0106310 - protein serine kinase activity GO:1902042 - negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2000145 - regulation of cell motility
Homologous interactions	19