HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~Ras, PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0030335 - positive regulation of cell migration GO:0043410 - positive regulation of MAPK cascade and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 839
+	Rn
		628680 RASH_RAT (16-189): 6.27e-73: 219: 100.00		NTRK1_RAT (31-839): 1.07e-171: 518: 46.81
+	Hs
		411698 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		NTRK1_HUMAN (16-839): 7.91e-171: 515: 47.95
+	Hs
		541423 RAB1A_HUMAN (4-186): 2.78e-74: 223: 31.28		FGFR1_HUMAN (204-838): 7.83e-164: 498: 24.47
+	Hs
		373888 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		ROR1_HUMAN (509-821): 2.64e-67: 243: 40.50
+	Hs
		373889 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56
+	Hs
		373733 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		INSR_HUMAN (513-824): 1.35e-64: 238: 39.43
+	Hs
		375424 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		ROR1_HUMAN (509-821): 2.64e-67: 243: 40.50
+	Hs
		375425 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56
+	Hs
		375086 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		INSR_HUMAN (513-824): 1.35e-64: 238: 39.43
+	Hs
		375099 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		IGF1R_HUMAN (513-820): 3.57e-64: 236: 39.16
+	Hs
		976213 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56
+	Hs
		374536 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		ROR1_HUMAN (509-821): 2.64e-67: 243: 40.50
+	Hs
		439696 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		INSR_HUMAN (513-824): 1.35e-64: 238: 39.43
+	Hs
		572912 RAB13_HUMAN (4-181): 1.29e-75: 227: 35.14		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		374340 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		INSR_HUMAN (513-824): 1.35e-64: 238: 39.43
+	Hs
		465472 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		IGF1R_HUMAN (513-820): 3.57e-64: 236: 39.16
+	Rn
		108121 G3V6H0_RAT (4-185): 5.56e-73: 220: 30.41		INSR_RAT (513-824): 3.32e-62: 230: 38.80
+	Rn
		580463 RB11A_RAT (4-178): 6.31e-73: 220: 33.90		INSR_RAT (513-824): 3.32e-62: 230: 38.80
+	Hs
		373908 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		PTK7_HUMAN (227-380): 1.86e-10: 67: 20.50
+	Hs
		375481 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		PTK7_HUMAN (227-380): 1.86e-10: 67: 20.50