HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	30442766, 30639242, 34079125, 37682707
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1116
+	Hs
		374939 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		374202 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		1145117 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		1144962 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		375620 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		376119 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA6_HUMAN (109-1116): 9.07e-88: 308: 28.41
+	Hs
		374532 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		ANK2_HUMAN (261-1106): 2.88e-56: 216: 10.80
+	Hs
		1140280 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		ACAP2_HUMAN (73-689): 4.4e-59: 220: 13.91
+	Dm
		473607 RAS1_DROME (1-165): 9.67e-88: 257: 85.46		Q7KNQ9_DROME (45-401): 9.43e-52: 201: 16.37
+	Hs
		375418 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		ANK2_HUMAN (261-1106): 2.88e-56: 216: 10.80
+	Hs
		1091402 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		375464 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		374148 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		MAGI1_HUMAN (1-537): 7.48e-44: 176: 12.32
+	Hs
		374203 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		375854 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		MAGI1_HUMAN (1-537): 7.48e-44: 176: 12.32
+	Hs
		1145118 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		375966 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Hs
		374137 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		ITCH_HUMAN (11-246): 4.77e-29: 127: 16.95
+	Hs
		374915 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		WWP1_HUMAN (6-240): 4.44e-23: 108: 15.48
+	Hs
		375841 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		ITCH_HUMAN (11-246): 4.77e-29: 127: 16.95