Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR
Interactor 2: LRP8 (Q14114)
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Gene: LRP8
Species: Homo sapiens
Source: biogrid
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 39499777 |
| Identification Methods | proximity labelling technology |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | EGF_CA~EGF_CA, EGF_CA~FXa_inhibition, EGF_CA~Ldl_recept_a, EGF_CA~Ldl_recept_b, FXa_inhibition~Ldl_recept_a, FXa_inhibition~Ldl_recept_b, Ldl_recept_a~Ldl_recept_a, Ldl_recept_a~Ldl_recept_b, Ldl_recept_b~Ldl_recept_b |
| Common GO terms | GO:0001523 - retinoid metabolic process GO:0001540 - amyloid-beta binding GO:0005041 - low-density lipoprotein particle receptor activity GO:0005509 - calcium ion binding GO:0005886 - plasma membrane and 6 others more... |
| Homologous interactions | 11 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
