Protein: LRP8
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

Gene: LRP8
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q14114

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001540 - amyloid-beta binding
GO:0004888 - transmembrane signaling receptor activity
GO:0005041 - low-density lipoprotein particle receptor activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1008064

RELN
Reelin

8

4

Small-scale

0.965

High

720473

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

10

Small-scale

0.947

High

1022515

VLDLR
Very low-density lipoprotein receptor

1

11

Small-scale

0.724

High

1120561

LRP8
Low-density lipoprotein receptor-related protein 8

1

11

Small-scale

0.724

High

387419

APOE
Apolipoprotein E

3

7

Small-scale

0.674

High

286368

DAB1
Disabled homolog 1

3

20

Small-scale

0.650

High

1120562

SNX17
Sorting nexin-17

2

4

Small-scale

0.646

High

376501

LDLR
Low-density lipoprotein receptor

1

11

High-throughput

0.618

High

388845

APOH
Beta-2-glycoprotein 1

1

6

Small-scale

0.618

High

472308

CFAH
Complement factor H

1

9

Small-scale

0.618

High

710234

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.618

High

778067

VGFR2
Vascular endothelial growth factor receptor 2

1

5

Small-scale

0.618

High

1051661

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

4

Small-scale

0.618

High

1103687

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

20

Small-scale

0.594

High

1120590

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.594

High

1006061

DLG4
Disks large homolog 4

2

8

Small-scale

0.586

High

218167

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.584

High

363268

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.584

High

630798

RAB4A
Ras-related protein Rab-4A

2

9

High-throughput

0.584

High

976260

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.584

High

1036650

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

12

Small-scale

0.561

High

1120569

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

668586

APC
Adenomatous polyposis coli protein

1

1

Small-scale

0.536

High

390042

ALBU
Albumin

1

1

High-throughput

0.536

High

1120588

NEB1
Neurabin-1

1

18

High-throughput

0.536

High

764743

CTNB1
Catenin beta-1

1

3

High-throughput

0.515

High

877111

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.515

High

1055314

APLP2
Amyloid beta precursor like protein 2

1

12

High-throughput

0.515

High

1120576

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.515

High

1120587

GGA1
ADP-ribosylation factor-binding protein GGA1

1

3

High-throughput

0.515

High

1055909

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

1120572

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.513

High

1120581

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.513

High

640592

MK
Midkine

1

5

Small-scale

0.501

High

1022159

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

1120578

NECA3
N-terminal EF-hand calcium-binding protein 3

1

0

High-throughput

0.493

High

1120564

ANGE2
Protein angel homolog 2

1

1

High-throughput

0.489

High

1120568

CRTC3
CREB-regulated transcription coactivator 3

1

1

High-throughput

0.489

High

1120584

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

1

High-throughput

0.489

High

161566

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.481

High

167602

GIPC1
PDZ domain-containing protein GIPC1

1

3

Small-scale

0.481

High

269764

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.481

High

1120580

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

1120583

SCN3A
Sodium channel protein type 3 subunit alpha

1

3

Small-scale

0.481

High

127079

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.479

High

189561

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

373923

RASN
GTPase NRas

1

12

High-throughput

0.479

High

375506

RASK
GTPase KRas

1

12

High-throughput

0.479

High

410834

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

422092

A4
Amyloid-beta precursor protein

1

13

Small-scale

0.479

High

562049

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

630514

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.479

High

631212

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

714619

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

4

High-throughput

0.479

High

774348

BASI
Basigin

1

5

High-throughput

0.479

High

900807

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

901231

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

901804

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

907422

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

944990

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

977999

RHOB
Rho-related GTP-binding protein RhoB

1

13

High-throughput

0.479

High

1041055

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1113072

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1120146

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

Small-scale

0.479

High

1120565

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1120566

FMN1
Formin-1

1

1

High-throughput

0.479

High

1120567

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1120585

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

1120591

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.479

High

116858

I6L9F6
NEFL protein

1

1

High-throughput

0.470

High

528251

THIO
Thioredoxin

1

3

High-throughput

0.470

High

1120579

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

High-throughput

0.470

High

975026

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1120563

SSXT
Protein SSXT

1

0

High-throughput

0.458

High

97049

E9PM19
Tyrosine-protein kinase

1

4

High-throughput

0.445

High

109335

G5E9A6
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

944381

SYJ2B
Synaptojanin-2-binding protein

1

17

Small-scale

0.439

High

1120589

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.439

High

956288

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.437

High

1120570

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1120574

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

3

Small-scale

0.408

High

1120573

CS047
Uncharacterized protein C19orf47

1

0

High-throughput

0.279

Low

1120575

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.279

Low

1120577

DOCK6
Dedicator of cytokinesis protein 6

1

0

High-throughput

0.279

Low

1120582

PKRI1
PRKR-interacting protein 1

1

0

High-throughput

0.279

Low

437167

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.269

Low

1120586

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low

1120571

DEN6A
Protein DENND6A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025