HitPredict

Interactor 1: MAS (P04201)
Proto-oncogene Mas
Gene: MAS1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 33339432
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 409
+	Hs
		428933 ADRB2_HUMAN (2-313): 2.13e-65: 213: 12.85		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		600742 C5AR1_HUMAN (37-324): 1.96e-66: 213: 22.62		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (1-323): 6.57e-67: 217: 13.51		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		685813 APJ_HUMAN (12-323): 1.28e-59: 197: 16.76		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685822 OPRD_HUMAN (16-323): 2.25e-59: 196: 17.52		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		674827 AGTR1_HUMAN (6-311): 4.36e-59: 195: 17.42		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		626614 AGTRA_RAT (20-311): 1.13e-59: 196: 17.56		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		600750 C5AR1_HUMAN (37-324): 1.96e-66: 213: 22.62		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		827197 MTR1L_HUMAN (11-301): 6.65e-60: 203: 10.97		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		781016 OPRD_HUMAN (16-323): 2.25e-59: 196: 17.52		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		674834 AGTR1_HUMAN (6-311): 4.36e-59: 195: 17.42		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		626613 AGTRA_RAT (20-311): 1.13e-59: 196: 17.56		ARRB1_RAT (1-399): 0: 654: 76.90
+	Mm
		669680 AGTRA_MOUSE (8-311): 4.36e-60: 197: 17.22		ARRB1_MOUSE (1-399): 0: 652: 76.90