HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: LIRB2 (Q8N423)
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
Gene: LILRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24018270
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~ig, C1-set~Ig_2, MHC_I~ig, Ig_2~MHC_I
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0006955 - immune response GO:0009986 - cell surface GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 597
+	Hs
		1325618 Q95J06_HUMAN (1-365): 0: 516: 92.33		LIRB2_HUMAN (1-597): 7.43e-130: 395: 100.00
+	Hs
		1209905 Q5S3G3_HUMAN (1-365): 4.3e-180: 505: 98.08		LIRB2_HUMAN (1-597): 7.43e-130: 395: 100.00
+	Hs
		1340138 Q95J06_HUMAN (1-365): 0: 516: 92.33		LIRB1_HUMAN (1-597): 5.34e-119: 369: 76.46
+	Hs
		409456 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		LIRB1_HUMAN (1-597): 5.34e-119: 369: 76.46
+	Hs
		1209906 Q5S3G3_HUMAN (1-365): 4.3e-180: 505: 98.08		LIRB1_HUMAN (1-597): 5.34e-119: 369: 76.46
+	Hs
		1133831 Q95J06_HUMAN (1-365): 0: 516: 92.33		KI3S1_HUMAN (1-344): 8.14e-67: 224: 37.93
+	Hs
		409383 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		KI3S1_HUMAN (1-344): 8.14e-67: 224: 37.93
+	Hs
		1133828 Q5SUL5_HUMAN (1-365): 1.92e-178: 501: 95.89		KI3S1_HUMAN (1-344): 8.14e-67: 224: 37.93
+	Hs
		409455 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		LIRB4_HUMAN (1-238): 8.5e-57: 199: 48.32
+	Hs
		850913 Q5S3G3_HUMAN (1-365): 4.3e-180: 505: 98.08		KI2S4_HUMAN (119-337): 4.27e-51: 180: 41.82
+	Hs
		850781 Q5RIP0_HUMAN (1-364): 1.3e-166: 471: 83.29		KI2L1_HUMAN (117-337): 5.35e-48: 173: 40.54
+	Hs
		850779 Q5D1W8_HUMAN (1-364): 5.49e-165: 467: 82.74		KI2L1_HUMAN (117-337): 5.35e-48: 173: 40.54
+	Hs
		850828 Q5S3G3_HUMAN (1-365): 4.3e-180: 505: 98.08		KI2L3_HUMAN (117-334): 1.48e-29: 121: 40.18
+	Hs
		47606 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		A0A8I5QEB2_HUMAN (317-447): 4.73e-18: 88.5: 32.06
+	Hs
		850827 Q5RIP0_HUMAN (1-364): 1.3e-166: 471: 83.29		KI2L3_HUMAN (117-334): 1.48e-29: 121: 40.18
+	Hs
		850806 Q5RIP0_HUMAN (1-364): 1.3e-166: 471: 83.29		KI2L2_HUMAN (117-334): 9.06e-29: 119: 39.09
+	Hs
		409302 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		KI3L2_HUMAN (323-597): 5.87e-16: 82.7: 20.19
+	Hs
		850823 Q5D1W8_HUMAN (1-364): 5.49e-165: 467: 82.74		KI2L3_HUMAN (117-334): 1.48e-29: 121: 40.18
+	Hs
		850877 Q5S3G3_HUMAN (1-365): 4.3e-180: 505: 98.08		KI3L2_HUMAN (323-597): 5.87e-16: 82.7: 20.19
+	Hs
		850804 Q5D1W8_HUMAN (1-364): 5.49e-165: 467: 82.74		KI2L2_HUMAN (117-334): 9.06e-29: 119: 39.09