HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: AFF4 (Q9UHB7)
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
Gene: AFF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	20153263, 21729782
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AF-4~AF-4, AF-4_C~AF-4_C
Common GO terms	GO:0008023 - transcription elongation factor complex GO:0010468 - regulation of gene expression GO:0032783 - super elongation complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1163
+	Hs
		850799 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		AFF1_HUMAN (4-1160): 4.79e-88: 312: 34.47
+	Hs
		850820 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		Q8TD98_HUMAN (305-773): 2.44e-30: 130: 32.92
+	Hs
		1231733 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		AN36B_HUMAN (555-1125): 1.21e-59: 226: 10.33
+	Hs
		1126898 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		AN36C_HUMAN (128-1125): 4.47e-53: 206: 9.50
+	Hs
		1231757 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		CHD7_HUMAN (73-891): 6.5e-25: 115: 12.85
+	Hs
		1154038 NIPBL_HUMAN (12-1005): 1.12e-50: 199: 12.27		NIPBL_HUMAN (91-887): 9.3e-18: 91.6: 16.10
+	Hs
		1231748 MINT_HUMAN (70-744): 7.76e-09: 62.7: 10.13		AN36B_HUMAN (555-1125): 1.21e-59: 226: 10.33
+	Hs
		1056827 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		MDC1_HUMAN (67-908): 1.82e-35: 149: 9.85
+	Hs
		1056876 MICA3_HUMAN (92-811): 7.34e-10: 65.8: 11.23		MDC1_HUMAN (67-908): 1.82e-35: 149: 9.85
+	Dm
		65570 FUTSC_DROME (18-979): 6.66e-12: 72.6: 11.09		A8JNM5_DROME (60-869): 2.36e-28: 126: 9.18
+	Mm
		1351630 PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27		PCLO_MOUSE (7-987): 3.87e-21: 102: 8.11
+	Dm
		113976 M9PB30_DROME (27-449): 7.87e-09: 62.8: 10.82		M9PB30_DROME (18-456): 1.29e-12: 75.1: 8.11
+	Hs
		152667 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56
+	Mm
		1207212 NCOA6_MOUSE (50-1088): 1.15e-11: 71.6: 9.93		KMT2C_MOUSE (181-1062): 2.36e-09: 64.3: 7.98
+	hg
		2814 A0A0C7TIF2_EBVG (90-773): 4.62e-09: 63.1: 16.19		A0A0C7TIF2_EBVG (394-900): 2.1e-11: 70.8: 14.73
+	Hs
		1057773 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56