HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 768
+	Hs
		409064 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042014 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042632 KRT84_HUMAN (3-644): 8.54e-97: 311: 44.36		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		318804 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		531563 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		943669 KRT85_HUMAN (69-552): 3.19e-81: 267: 44.88		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		380472 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		318805 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1041394 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		318806 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		943670 KRT85_HUMAN (69-552): 3.19e-81: 267: 44.88		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		531564 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		943671 KRT85_HUMAN (69-552): 3.19e-81: 267: 44.88		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		318802 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		531561 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		380471 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		318803 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		531562 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		318858 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		531614 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CUL5_HUMAN (25-768): 0: 597: 23.77