HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: KT33B (Q14525)
Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)
Gene: KRT33B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.875

Property	Details
Experiments	25910212, 32296183, unassigned1304
Identification Methods	two hybrid, split luciferase complementation, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005615 - extracellular space GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 404
+	Hs
		280845 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT37_HUMAN (17-398): 9.79e-151: 435: 61.10
+	Hs
		409116 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C40_HUMAN (6-402): 5.14e-145: 420: 59.65
+	Hs
		359290 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C14_HUMAN (54-367): 2.81e-143: 417: 60.51
+	Hs
		408980 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C19_HUMAN (49-366): 1.39e-142: 413: 55.98
+	Mm
		1322195 K2C7_MOUSE (138-538): 3.51e-141: 421: 58.35		K1C17_MOUSE (49-368): 2.08e-144: 419: 58.75
+	Hs
		409054 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C17_HUMAN (49-367): 1.46e-113: 340: 59.88
+	Hs
		408981 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C16_HUMAN (54-369): 2.62e-110: 333: 59.81
+	Hs
		409000 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C15_HUMAN (55-367): 8.45e-107: 323: 57.33
+	Hs
		444534 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		K1C17_HUMAN (49-367): 1.46e-113: 340: 59.88
+	Hs
		408990 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C13_HUMAN (50-373): 3.03e-104: 317: 55.08
+	Hs
		49549 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		A1A4E9_HUMAN (50-373): 2.08e-103: 315: 54.46
+	Mm
		444567 K2C7_MOUSE (138-538): 3.51e-141: 421: 58.35		K1C13_MOUSE (52-367): 4.27e-105: 318: 56.47
+	Hs
		280943 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT38_HUMAN (9-403): 3.34e-92: 286: 62.12
+	Hs
		280508 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT34_HUMAN (1-388): 2.98e-92: 284: 89.95
+	Hs
		409072 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1H2_HUMAN (5-402): 4.61e-84: 265: 66.67
+	Hs
		409184 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT35_HUMAN (2-402): 3.37e-80: 255: 67.41
+	Hs
		409071 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KT33B_HUMAN (1-404): 4.27e-80: 253: 100.00
+	Hs
		409082 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1H1_HUMAN (1-392): 8.95e-80: 253: 94.64
+	Hs
		280646 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		KRT34_HUMAN (1-388): 2.98e-92: 284: 89.95
+	Hs
		280770 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT36_HUMAN (4-403): 3.13e-78: 250: 68.75