Protein: DRB3
HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)

Gene: DRB3, HLA-DRB3
Organism: Homo sapiens
Interactions: 68
UniProt ID: P79483

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002250 - adaptive immune response
GO:0002469 - myeloid dendritic cell antigen processing and presentation
GO:0002503 - peptide antigen assembly with MHC class II protein complex
GO:0002842 - positive regulation of T cell mediated immune response to tumor cell

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249378

MPZL2
Myelin protein zero-like protein 2

1

15

High-throughput

0.691

High

380278

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

18

High-throughput

0.691

High

380415

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

19

High-throughput

0.691

High

380623

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

18

High-throughput

0.691

High

407075

HG2A
HLA class II histocompatibility antigen gamma chain

1

8

High-throughput

0.691

High

409348

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

18

High-throughput

0.691

High

520810

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

18

High-throughput

0.691

High

568052

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

18

High-throughput

0.691

High

607360

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

18

High-throughput

0.691

High

627516

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

19

High-throughput

0.691

High

719708

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

18

High-throughput

0.691

High

1009141

IDD
Integral membrane protein DGCR2/IDD

1

10

High-throughput

0.691

High

1009143

KLRD1
Natural killer cells antigen CD94

1

20

High-throughput

0.691

High

1009146

HFE
Hereditary hemochromatosis protein

1

20

High-throughput

0.691

High

1009156

RN149
E3 ubiquitin-protein ligase RNF149

1

13

High-throughput

0.691

High

1009169

CLC2D
C-type lectin domain family 2 member D

1

20

High-throughput

0.691

High

1009170

BTNL2
Butyrophilin-like protein 2

1

15

High-throughput

0.691

High

299870

C1QRF
C1q-related factor

1

3

High-throughput

0.618

High

1009153

ZDH17
Palmitoyltransferase ZDHHC17

1

3

High-throughput

0.590

High

212018

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

2

High-throughput

0.541

High

61099

T131L
Transmembrane protein 131-like

1

9

High-throughput

0.536

High

292612

RENR
Renin receptor

1

3

High-throughput

0.536

High

376495

LDLR
Low-density lipoprotein receptor

1

3

High-throughput

0.536

High

507157

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

5

High-throughput

0.536

High

534929

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.536

High

565596

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

14

High-throughput

0.536

High

1006006

ASIC1
Acid-sensing ion channel 1

1

17

High-throughput

0.536

High

1009142

DNJC3
DnaJ homolog subfamily C member 3

1

8

High-throughput

0.536

High

1009144

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

1

High-throughput

0.536

High

1009145

STAR3
StAR-related lipid transfer protein 3

1

3

High-throughput

0.536

High

1009150

AGRF1
Adhesion G-protein coupled receptor F1

1

8

High-throughput

0.536

High

1009151

I27RA
Interleukin-27 receptor subunit alpha

1

10

High-throughput

0.536

High

1009152

TBA1A
Tubulin alpha-1A chain

1

8

High-throughput

0.536

High

1009155

ABD12
Lysophosphatidylserine lipase ABHD12

1

3

High-throughput

0.536

High

1009159

T106A
Transmembrane protein 106A

1

17

High-throughput

0.536

High

1009161

ASIC4
Acid-sensing ion channel 4

1

17

High-throughput

0.536

High

1009162

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

High-throughput

0.536

High

1009163

CSTN3
Calsyntenin-3

1

10

High-throughput

0.536

High

1009164

CHST8
Carbohydrate sulfotransferase 8

1

12

High-throughput

0.536

High

1009165

SDF2L
Stromal cell-derived factor 2-like protein 1

1

5

High-throughput

0.536

High

1009166

CNNM1
Metal transporter CNNM1

1

11

High-throughput

0.536

High

1009167

T106B
Transmembrane protein 106B

1

17

High-throughput

0.536

High

1009171

ITM2B
Integral membrane protein 2B

1

10

High-throughput

0.536

High

1009173

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

10

High-throughput

0.536

High

697841

CALR
Calreticulin

1

11

High-throughput

0.515

High

787978

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.515

High

1009158

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.513

High

1009174

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

289313

FCN3
Ficolin-3

1

2

High-throughput

0.489

High

547996

PSPC
Surfactant protein C

1

7

High-throughput

0.489

High

1009147

TBB8
Tubulin beta-8 chain

1

4

High-throughput

0.489

High

1009149

MKS3
Meckelin

1

6

High-throughput

0.489

High

1009154

NNRD
ATP-dependent

1

1

High-throughput

0.489

High

1009160

SARAF
Store-operated calcium entry-associated regulatory factor

1

5

High-throughput

0.489

High

1009172

DJC16
DnaJ homolog subfamily C member 16

1

11

High-throughput

0.489

High

343845

SEM4F
Semaphorin-4F

1

15

High-throughput

0.479

High

420785

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

8

Small-scale

0.479

High

461353

HS90A
Heat shock protein HSP 90-alpha

1

10

Small-scale

0.479

High

468263

HS90B
Heat shock protein HSP 90-beta

1

10

Small-scale

0.479

High

536957

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

549436

CD20
B-lymphocyte antigen CD20

1

3

Small-scale

0.479

High

573063

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

899684

ANX11
Annexin A11

1

5

Small-scale

0.479

High

971399

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

1009157

NEK7
Serine/threonine-protein kinase Nek7

1

6

High-throughput

0.470

High

377054

COLI
Pro-opiomelanocortin

1

0

Small-scale

0.426

High

1009168

SELN
Selenoprotein N

3

0

High-throughput

0.347

High

1009148

BOREA
Borealin

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025