HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: B2MG (P61769)
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Gene: B2M

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 34384783, 8805302, 24018270
Identification Methods x-ray crystallography, affinity chromatography technology, pull down, surface plasmon resonance
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~C1-set, C1-set~MHC_I
Common GO terms GO:0000139 - Golgi membrane
GO:0001913 - T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002502 - peptide antigen assembly with MHC class I protein complex
GO:0002726 - positive regulation of T cell cytokine production
and 15 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 365
Hs

1 119
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024