HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	14720327, 28680062, 32238831, 11163245, 12665567, 12566391, 10097092, 15005629, 24361270
Identification Methods	enzymatic study, x-ray crystallography, classical fluorescence spectroscopy, nuclear magnetic resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~HAT_KAT11
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 2442
+	Hs
		980051 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		PHIP_HUMAN (1045-1205): 3.24e-45: 183: 30.36
+	Zm
		19410 A0A1D6IAU4_MAIZE (1-103): 4.99e-53: 163: 98.06		A0A1D6HCG5_MAIZE (976-1204): 3.56e-42: 169: 26.28
+	Dm
		1014781 H4_DROME (1-103): 4.53e-48: 150: 99.03		Q4V5A7_DROME (1057-1356): 1.68e-42: 169: 18.75
+	Hs
		180769 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		TIF1A_HUMAN (667-1202): 2.18e-34: 147: 17.97
+	Mm
		980667 H4_MOUSE (1-103): 1.39e-48: 151: 100.00		BRDT_MOUSE (1057-1195): 7.41e-34: 145: 25.90
+	Hs
		674123 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		BRD2_HUMAN (1065-1195): 9.69e-34: 143: 30.53
+	Hs
		979687 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		BRD3_HUMAN (1073-1195): 1.37e-33: 143: 30.89
+	Sp
		480426 H4_SCHPO (18-103): 4.89e-42: 135: 89.54		YK82_SCHPO (698-1194): 3.04e-33: 141: 14.06
+	Sc
		382022 H4_YEAST (18-103): 6.16e-41: 132: 90.70		BDF1_YEAST (1024-1207): 1.45e-32: 139: 21.51
+	Sc
		382376 H4_YEAST (18-103): 6.16e-41: 132: 90.70		BDF2_YEAST (1040-1284): 8.12e-26: 117: 15.91
+	Hs
		979908 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		PB1_HUMAN (1040-1195): 4.73e-12: 74.4: 19.87
+	Hs
		980464 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD7_HUMAN (105-479): 4.97e-11: 71: 9.19
+	Hs
		980015 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		KMT2C_HUMAN (1839-2361): 2.29e-10: 68.7: 10.22
+	Hs
		979558 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		EP300_HUMAN (1789-2434): 7.34e-09: 63.6: 13.61
+	Sc
		382306 H4_YEAST (18-103): 6.16e-41: 132: 90.70		GCN5_YEAST (1110-1192): 5.78e-12: 72.4: 37.35
+	Hs
		1067633 H4G_HUMAN (1-98): 1.04e-38: 126: 84.69		EP300_HUMAN (1789-2434): 7.34e-09: 63.6: 13.61