HitPredict

Interactor 1: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Interactor 2: PSD10 (Q9Z2X2)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin)
Gene: Psmd10

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30109252
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~P53, Ank~P53_tetramer, Ank_2~P53_tetramer
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 390 Mm			1 231
+	Hs
		413644 P53_HUMAN (4-390): 0: 578: 77.35		ANK2_HUMAN (4-231): 1.93e-66: 223: 28.30
+	Hs
		414623 P53_HUMAN (4-390): 0: 578: 77.35		Q9H4D1_HUMAN (10-231): 5.73e-55: 189: 25.56
+	Hs
		295443 P53_HUMAN (4-390): 0: 578: 77.35		PSD10_HUMAN (44-231): 4.59e-52: 169: 30.89
+	Hs
		413730 P53_HUMAN (4-390): 0: 578: 77.35		ANK3_HUMAN (80-227): 3.23e-45: 162: 33.78
+	Hs
		414644 P53_HUMAN (4-390): 0: 578: 77.35		EHMT1_HUMAN (2-153): 4.05e-43: 156: 24.34
+	Mm
		382499 P53_MOUSE (1-390): 0: 622: 100.00		DAPK1_MOUSE (2-100): 4.63e-20: 90.5: 16.16
+	Hs
		413461 P53_HUMAN (4-390): 0: 578: 77.35		DAPK1_HUMAN (2-100): 1.25e-20: 92: 17.17
+	Hs
		414147 P53_HUMAN (4-390): 0: 578: 77.35		MIB1_HUMAN (9-146): 2.98e-17: 82.1: 20.95
+	Hs
		171150 P53_HUMAN (4-390): 0: 578: 77.35		MYPT1_HUMAN (9-92): 8.01e-10: 60.2: 17.86