HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0030425 - dendrite GO:0043025 - neuronal cell body
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 411
+	Hs
		384583 NTRK1_HUMAN (1-796): 0: 621: 100.00		IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75
+	Hs
		384224 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63
+	Hs
		385284 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX17_HUMAN (14-411): 1.24e-132: 399: 30.79
+	Hs
		133833 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45
+	Hs
		384295 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83
+	Hs
		435566 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00