Protein: BAK
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)

Gene: BAK, BAK1
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q16611

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process
GO:0001836 - release of cytochrome c from mitochondria
GO:0001974 - blood vessel remodeling
GO:0002262 - myeloid cell homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060264

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

26

18

Small-scale

0.991

High

1060173

B2CL1
Bcl-2-like protein 1

23

17

Small-scale

0.991

High

1159442

BAK
Bcl-2 homologous antagonist/killer

6

17

Small-scale

0.944

High

1060087

BAX
Apoptosis regulator BAX

6

17

Small-scale

0.935

High

522102

BCL2
Apoptosis regulator Bcl-2

6

17

Small-scale

0.930

High

1159451

B2CL2
Bcl-2-like protein 2

5

17

Small-scale

0.927

High

413926

P53
Cellular tumor antigen p53

4

9

Small-scale

0.893

High

939628

BID
BH3-interacting domain death agonist

4

10

Small-scale

0.885

High

1158633

B2LA1
Bcl-2-related protein A1

3

18

High-throughput

0.871

High

1151471

IKBB
NF-kappa-B inhibitor beta

1

4

Small-scale

0.647

High

219633

B2L11
Bcl-2-like protein 11

1

17

Small-scale

0.618

High

1126695

BECN1
Beclin-1

1

8

Small-scale

0.618

High

1159453

B2L10
Bcl-2-like protein 10

1

4

Small-scale

0.618

High

852763

VDAC2
Non-selective voltage-gated ion channel VDAC2

2

8

Small-scale

0.601

High

326567

MFN2
Mitofusin-2

2

3

Small-scale

0.584

High

1159448

MFN1
Mitofusin-1

2

3

Small-scale

0.584

High

1050432

UBE3A
Ubiquitin-protein ligase E3A

1

4

Small-scale

0.578

High

640900

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

8

Small-scale

0.561

High

130841

DFFA
DNA fragmentation factor subunit alpha

1

1

High-throughput

0.515

High

287933

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.515

High

958278

ARP2
Actin-related protein 2

1

3

High-throughput

0.515

High

1086362

AKP13
A-kinase anchor protein 13

1

1

High-throughput

0.515

High

245953

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

361263

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

415599

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.515

High

890739

PSN2
Presenilin-2

1

4

High-throughput

0.515

High

1145954

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.493

High

705359

GRN
Progranulin

1

0

High-throughput

0.493

High

1159446

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1159450

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

1159454

ATX10
Ataxin-10

1

0

High-throughput

0.493

High

912572

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.486

High

397739

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

Small-scale

0.479

High

532613

CH60
60 kDa heat shock protein, mitochondrial

1

7

Small-scale

0.479

High

853692

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.479

High

1159444

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1159445

BOP
Protein Bop

1

6

Small-scale

0.479

High

1159455

SRRM2
Serine/arginine repetitive matrix protein 2

1

2

High-throughput

0.470

High

109411

G5E9A7
DM1 locus, WD repeat containing

1

3

High-throughput

0.470

High

1159456

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

906414

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.460

High

1159449

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

1159457

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.445

High

75673

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

1004625

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1159452

GIMA5
GTPase IMAP family member 5

1

5

Small-scale

0.437

High

1153157

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

5

Small-scale

0.408

High

69496

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

321913

FRYL
Protein furry homolog-like

1

0

High-throughput

0.269

Low

643864

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.269

Low

1159447

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1159443

DREB
Drebrin

1

0

High-throughput

0.265

Low

517229

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025