HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: LIPB1 (Q86W92)
Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2)
Gene: PPFIBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1011
+	Hs
		508083 FGFR1_HUMAN (195-794): 0: 545: 26.34		LIPB1_HUMAN (1-1011): 7.51e-135: 433: 100.00
+	Hs
		1083863 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		LIPB1_HUMAN (1-1011): 7.51e-135: 433: 100.00
+	Hs
		608029 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		LIPB1_HUMAN (1-1011): 7.51e-135: 433: 100.00
+	Hs
		384981 NTRK1_HUMAN (1-796): 0: 621: 100.00		MRCKA_HUMAN (50-632): 1.12e-35: 149: 15.57
+	Hs
		384384 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH9_HUMAN (2-781): 5.58e-30: 131: 7.15
+	Hs
		384385 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH10_HUMAN (2-784): 3.65e-29: 128: 8.24
+	Hs
		385184 NTRK1_HUMAN (1-796): 0: 621: 100.00		LIPB2_HUMAN (1-360): 1.13e-17: 90.7: 45.48
+	Hs
		608068 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		ANS1A_HUMAN (502-904): 1.42e-45: 180: 15.23
+	Hs
		384757 NTRK1_HUMAN (1-796): 0: 621: 100.00		LIPA1_HUMAN (1-598): 1.48e-09: 64.2: 9.82
+	Hs
		384180 NTRK1_HUMAN (1-796): 0: 621: 100.00		TPR_HUMAN (70-620): 8.21e-09: 62.3: 10.65
+	Hs
		507974 FGFR1_HUMAN (195-794): 0: 545: 26.34		LIPA1_HUMAN (1-598): 1.48e-09: 64.2: 9.82
+	Mm
		546301 NTRK2_MOUSE (12-796): 2.75e-174: 524: 47.32		KINH_MOUSE (128-514): 3.14e-11: 69.6: 12.63
+	Hs
		1025293 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		LIPA1_HUMAN (1-598): 1.48e-09: 64.2: 9.82
+	Hs
		607953 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		LIPA1_HUMAN (1-598): 1.48e-09: 64.2: 9.82
+	Hs
		518818 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		TPR_HUMAN (70-620): 8.21e-09: 62.3: 10.65
+	Hs
		665375 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		MYH9_HUMAN (2-781): 5.58e-30: 131: 7.15
+	Hs
		725069 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		MYH9_HUMAN (2-781): 5.58e-30: 131: 7.15
+	Hs
		725268 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		MYH10_HUMAN (2-784): 3.65e-29: 128: 8.24
+	Hs
		666590 LTK_HUMAN (502-790): 3.09e-60: 221: 41.64		LIPA1_HUMAN (1-598): 1.48e-09: 64.2: 9.82