HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: AP1M1 (Q9BXS5)
AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)
Gene: AP1M1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 423
+	Hs
		508180 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP1M1_HUMAN (1-423): 0: 528: 100.00
+	Hs
		385759 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP3M1_HUMAN (3-422): 5.32e-127: 375: 26.73
+	Hs
		508141 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Mm
		546292 NTRK2_MOUSE (12-796): 2.75e-174: 524: 47.32		AP2M1_MOUSE (3-421): 3.27e-155: 447: 38.85
+	Hs
		609222 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		AP3M2_HUMAN (3-422): 2.67e-123: 365: 25.81
+	Rn
		544829 INSR_RAT (493-777): 7.31e-66: 241: 41.95		AP1M1_RAT (1-423): 0: 527: 99.53
+	Hs
		608213 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		STON1_HUMAN (125-423): 9.89e-68: 230: 19.43
+	Hs
		384466 NTRK1_HUMAN (1-796): 0: 621: 100.00		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		1088134 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Rn
		544815 INSR_RAT (493-777): 7.31e-66: 241: 41.95		AP2M1_RAT (3-421): 3.27e-155: 447: 38.85
+	Hs
		507910 FGFR1_HUMAN (195-794): 0: 545: 26.34		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		818949 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	At
		187748 BAME3_ARATH (238-389): 6.12e-09: 62: 6.94		AP2M_ARATH (1-421): 1.44e-160: 461: 44.04
+	Hs
		818906 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		411333 INSR_HUMAN (493-777): 3e-68: 248: 42.62		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Rn
		1146015 T2CB11_RAT (493-777): 7.32e-66: 241: 41.95		COPD_RAT (8-165): 1.37e-18: 89.7: 17.72
+	Rn
		544885 INSR_RAT (493-777): 7.31e-66: 241: 41.95		COPD_RAT (8-165): 1.37e-18: 89.7: 17.72
+	Hs
		818923 ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		819048 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		169166 MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72