HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15020686, 19331827
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 870
+	Hs
		397225 ESR1_HUMAN (1-595): 0: 599: 100.00		MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79
+	Hs
		395953 ESR1_HUMAN (1-595): 0: 599: 100.00		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		395433 ESR1_HUMAN (1-595): 0: 599: 100.00		MUC1_HUMAN (53-766): 3.75e-35: 146: 11.68
+	Hs
		396370 ESR1_HUMAN (1-595): 0: 599: 100.00		DNMBP_HUMAN (7-561): 3.15e-28: 125: 14.87
+	Hs
		274071 ESR1_HUMAN (1-595): 0: 599: 100.00		ANR17_HUMAN (69-494): 5.56e-27: 121: 14.82
+	Hs
		396114 ESR1_HUMAN (1-595): 0: 599: 100.00		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		1367596 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79
+	Hs
		396547 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (103-742): 7.2e-12: 71.8: 10.09
+	Hs
		396612 ESR1_HUMAN (1-595): 0: 599: 100.00		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		1040346 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Hs
		590324 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		MUC1_HUMAN (53-766): 3.75e-35: 146: 11.68
+	Hs
		274214 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		ANR17_HUMAN (69-494): 5.56e-27: 121: 14.82
+	Hs
		1129670 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		1367026 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		CHAP1_HUMAN (74-473): 9.53e-21: 100: 15.99
+	Hs
		1338263 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		KMT2C_HUMAN (103-742): 7.2e-12: 71.8: 10.09
+	Hs
		1367725 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PCLO_HUMAN (47-739): 1.74e-09: 64.2: 10.61
+	Hs
		1361882 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		274073 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		ANR17_HUMAN (69-494): 5.56e-27: 121: 14.82
+	Hs
		833993 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		KMT2C_HUMAN (103-742): 7.2e-12: 71.8: 10.09
+	Hs
		404273 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93