HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 2752
+	Hs
		833836 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		834148 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1335031 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		625642 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1268608 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		807687 CDK3_HUMAN (160-495): 1.29e-125: 370: 24.20		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		807717 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		1301016 DYR1B_HUMAN (108-488): 2.22e-110: 342: 29.03		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		833803 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		MINT_HUMAN (709-2695): 5.55e-37: 157: 9.30
+	Hs
		415030 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Dm
		834170 DOA_DROME (8-494): 4.91e-114: 357: 51.83		Q7YZ99_DROME (1-876): 3.94e-54: 210: 21.48
+	Hs
		944676 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		MAP1A_HUMAN (170-2540): 2.1e-44: 181: 9.15
+	Hs
		311795 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		TACC2_HUMAN (1893-2744): 4.03e-13: 78.2: 8.34
+	Hs
		70875 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		B2RWP4_HUMAN (1893-2744): 4.01e-13: 78.2: 8.34
+	Hs
		1268591 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TARA_HUMAN (1540-2752): 1.5e-31: 138: 11.50
+	Hs
		625528 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Dm
		834172 DOA_DROME (8-494): 4.91e-114: 357: 51.83		Q86BP9_DROME (99-266): 2.01e-28: 115: 25.60
+	Hs
		1264773 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Ce
		246633 MBK2_CAEEL (145-487): 5.44e-111: 349: 27.93		O61201_CAEEL (520-2145): 3.23e-14: 81.8: 12.70
+	Hs
		152642 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		KMT2D_HUMAN (10-501): 7.91e-09: 63.9: 11.75