HitPredict

Interactor 1: IF2A (P05198)
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)
Gene: EIF2S1

Interactor 2: IF2B (P20042)
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)
Gene: EIF2S2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	30699057, 11041858, 26186194, 28514442, 33961781, 16288713
Identification Methods	affinity chromatography technology, pull down, enzyme linked immunosorbent assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0005850 - eukaryotic translation initiation factor 2 complex GO:0006413 - translational initiation and 1 others more... GO:0045202 - synapse
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 333
+	Sc
		447154 IF2A_YEAST (1-297): 2.57e-117: 342: 53.69		IF2B_YEAST (71-328): 1.04e-77: 241: 42.48
+	Hs
		398673 IF2A_HUMAN (1-315): 8.85e-149: 422: 100.00		IF5_HUMAN (191-308): 2.28e-41: 151: 24.00
+	Sc
		593843 IF2A_YEAST (1-297): 2.57e-117: 342: 53.69		IF5_YEAST (184-311): 4.96e-38: 141: 24.06
+	Pf
		1211835 IF2A_PLAF7 (5-306): 1.19e-104: 310: 48.36		Q8I5X8_PLAF7 (185-307): 5.95e-41: 152: 25.81
+	Hv
		89139 D4GT46_HALVD (11-268): 3.56e-71: 223: 20.39		D4GVV8_HALVD (176-312): 1.56e-47: 160: 29.93
+	Hv
		89148 D4GT46_HALVD (11-268): 3.56e-71: 223: 20.39		D4GZP2_HALVD (176-314): 4.23e-47: 157: 30.94