Protein: KLK2
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)

Gene: KLK2
Organism: Homo sapiens
Interactions: 114
UniProt ID: P20151

Gene Ontology (top 5):
GO:0003073 - regulation of systemic arterial blood pressure
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0030141 - secretory granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450170

GDN
Glia-derived nexin

3

20

High-throughput

0.861

High

628405

APLP2
Amyloid beta precursor like protein 2

3

12

High-throughput

0.861

High

628392

SPB6
Serpin B6

2

20

Small-scale

0.768

High

287523

LRP6
Low-density lipoprotein receptor-related protein 6

1

18

High-throughput

0.691

High

562693

BMP1
Bone morphogenetic protein 1

1

16

High-throughput

0.691

High

369437

AACT
Alpha-1-antichymotrypsin

1

20

Small-scale

0.647

High

421478

A4
Amyloid-beta precursor protein

1

15

High-throughput

0.647

High

475218

A2AP
Alpha-2-antiplasmin

1

20

Small-scale

0.647

High

628403

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

13

High-throughput

0.618

High

628475

JAG2
Protein jagged-2

1

9

High-throughput

0.618

High

425167

IPSP
Plasma serine protease inhibitor

1

20

Small-scale

0.618

High

628436

GSLG1
Golgi apparatus protein 1

2

2

High-throughput

0.611

High

251070

B4GT3
Beta-1,4-galactosyltransferase 3

1

5

High-throughput

0.536

High

582070

PGAM2
Phosphoglycerate mutase 2

1

1

High-throughput

0.536

High

628389

FGFR4
Fibroblast growth factor receptor 4

1

9

High-throughput

0.536

High

628390

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

18

High-throughput

0.536

High

628419

ARSK
Arylsulfatase K

1

11

High-throughput

0.536

High

628428

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

7

High-throughput

0.536

High

628437

EXT2
Exostosin-2

1

8

High-throughput

0.536

High

628444

I17RA
Interleukin-17 receptor A

1

4

High-throughput

0.536

High

628456

CHID1
Chitinase domain-containing protein 1

1

3

High-throughput

0.536

High

628476

MA2B2
Epididymis-specific alpha-mannosidase

1

10

High-throughput

0.536

High

136593

MANBA
Beta-mannosidase

1

4

High-throughput

0.489

High

628397

MA2A2
Alpha-mannosidase 2x

1

10

High-throughput

0.489

High

628415

GT253
Inactive glycosyltransferase 25 family member 3

1

7

High-throughput

0.489

High

628417

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

15

High-throughput

0.489

High

628427

SUMF1
Formylglycine-generating enzyme

1

4

High-throughput

0.489

High

628438

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.489

High

628439

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

4

High-throughput

0.489

High

519731

ANDR
Androgen receptor

1

9

Small-scale

0.479

High

628473

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

16

High-throughput

0.479

High

628396

UTRN
Utrophin

1

4

High-throughput

0.445

High

628409

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

2

High-throughput

0.445

High

628457

TB10A
TBC1 domain family member 10A

1

2

High-throughput

0.445

High

628472

DKK3
Dickkopf-related protein 3

1

2

High-throughput

0.445

High

628451

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.437

High

628445

VPS50
Syndetin

1

0

High-throughput

0.426

High

61423

VWA8
von Willebrand factor A domain-containing protein 8

1

3

High-throughput

0.407

High

171666

GAK
Cyclin-G-associated kinase

1

4

High-throughput

0.407

High

220566

AKA10
A-kinase anchor protein 10, mitochondrial

1

1

High-throughput

0.407

High

229410

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

7

High-throughput

0.407

High

249959

OGA
Protein O-GlcNAcase

1

1

High-throughput

0.407

High

271664

HIP1R
Huntingtin-interacting protein 1-related protein

1

2

High-throughput

0.407

High

291901

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

8

High-throughput

0.407

High

335674

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

3

High-throughput

0.407

High

547089

PYC
Pyruvate carboxylase, mitochondrial

1

5

High-throughput

0.407

High

577405

ETS1
Protein C-ets-1

1

6

High-throughput

0.407

High

628391

TTK
Dual specificity protein kinase TTK

1

3

High-throughput

0.407

High

628393

CASP3
Caspase-3

1

2

High-throughput

0.407

High

628394

MK08
Mitogen-activated protein kinase 8

1

2

High-throughput

0.407

High

628395

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

6

High-throughput

0.407

High

628399

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.407

High

628401

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

9

High-throughput

0.407

High

628406

SKP2
S-phase kinase-associated protein 2

1

1

High-throughput

0.407

High

628407

RAB32
Ras-related protein Rab-32

1

9

High-throughput

0.407

High

628410

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.407

High

628411

SKI2
Superkiller complex protein 2

1

3

High-throughput

0.407

High

628412

ERC6L
DNA excision repair protein ERCC-6-like

1

10

High-throughput

0.407

High

628414

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.407

High

628418

SKI3
Superkiller complex protein 3

1

6

High-throughput

0.407

High

628420

AACS
Acetoacetyl-CoA synthetase

1

6

High-throughput

0.407

High

628421

MEX3D
RNA-binding protein MEX3D

1

1

High-throughput

0.407

High

628422

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

1

High-throughput

0.407

High

628423

LMTK2
Serine/threonine-protein kinase LMTK2

1

11

High-throughput

0.407

High

628424

EXOC8
Exocyst complex component 8

1

1

High-throughput

0.407

High

628425

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.407

High

628429

DHB11
Estradiol 17-beta-dehydrogenase 11

1

13

High-throughput

0.407

High

628430

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

6

High-throughput

0.407

High

628431

RDH11
Retinol dehydrogenase 11

1

3

High-throughput

0.407

High

628432

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.407

High

628434

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

4

High-throughput

0.407

High

628440

FAKD4
FAST kinase domain-containing protein 4

1

6

High-throughput

0.407

High

628441

HOOK2
Protein Hook homolog 2

1

3

High-throughput

0.407

High

628442

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.407

High

628443

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

1

3

High-throughput

0.407

High

628446

VCIP1
Deubiquitinating protein VCPIP1

1

2

High-throughput

0.407

High

628447

PASK
PAS domain-containing serine/threonine-protein kinase

1

4

High-throughput

0.407

High

628448

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

4

High-throughput

0.407

High

628449

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

5

High-throughput

0.407

High

628450

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.407

High

628453

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

5

High-throughput

0.407

High

628454

METH
Methionine synthase

1

1

High-throughput

0.407

High

628455

HGH1
Protein HGH1 homolog

1

1

High-throughput

0.407

High

628458

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

1

High-throughput

0.407

High

628461

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

2

High-throughput

0.407

High

628462

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

6

High-throughput

0.407

High

628463

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.407

High

628464

NEK6
Serine/threonine-protein kinase Nek6

1

5

High-throughput

0.407

High

628465

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.407

High

628467

STRN4
Striatin-4

1

2

High-throughput

0.407

High

628468

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

4

High-throughput

0.407

High

628469

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.407

High

628470

INT9
Integrator complex subunit 9

1

1

High-throughput

0.407

High

628477

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.407

High

628478

KAD6
Adenylate kinase isoenzyme 6

1

1

High-throughput

0.407

High

628479

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.407

High

628408

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

214384

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low

278809

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.232

Low

628398

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.232

Low

628400

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.232

Low

628402

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.232

Low

628404

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.232

Low

628413

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.232

Low

628416

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.232

Low

628426

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.232

Low

628433

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low

628435

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.232

Low

628452

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

High-throughput

0.232

Low

628459

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.232

Low

628460

SHRPN
Sharpin

1

0

High-throughput

0.232

Low

628466

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.232

Low

628471

PANK4
4'-phosphopantetheine phosphatase

1

0

High-throughput

0.232

Low

628474

FBX9
F-box only protein 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025