Protein: UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)

Gene: UCHL5
Organism: Homo sapiens
Interactions: 248
UniProt ID: Q9Y5K5

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0003723 - RNA binding
GO:0004843 - cysteine-type deubiquitinase activity
GO:0004866 - endopeptidase inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1081052

ADRM1
Proteasomal ubiquitin receptor ADRM1

25

4

Small-scale

0.993

High

476639

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

14

15

Small-scale

0.984

High

1378077

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

6

6

Small-scale

0.950

High

872326

RD23B
UV excision repair protein RAD23 homolog B

3

17

Small-scale

0.839

High

1262008

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

1

Small-scale

0.789

High

1159821

NFRKB
Nuclear factor related to kappa-B-binding protein

14

3

Small-scale

0.763

High

632965

TYY1
Transcriptional repressor protein YY1

9

1

Small-scale

0.757

High

874206

PSMD4
26S proteasome non-ATPase regulatory subunit 4

10

2

Small-scale

0.756

High

131122

PSDE
26S proteasome non-ATPase regulatory subunit 14

11

10

Small-scale

0.756

High

229184

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

872237

RD23A
UV excision repair protein RAD23 homolog A

2

14

Small-scale

0.754

High

1136661

DDI2
Protein DDI1 homolog 2

2

6

Small-scale

0.754

High

1027841

PSMD2
26S proteasome non-ATPase regulatory subunit 2

9

6

Small-scale

0.754

High

121884

PSD11
26S proteasome non-ATPase regulatory subunit 11

8

9

Small-scale

0.751

High

122113

PSD12
26S proteasome non-ATPase regulatory subunit 12

8

6

Small-scale

0.751

High

198766

PSMD3
26S proteasome non-ATPase regulatory subunit 3

8

4

Small-scale

0.751

High

573123

PRS6A
26S proteasome regulatory subunit 6A

8

13

Small-scale

0.751

High

730395

PRS7
26S proteasome regulatory subunit 7

8

8

Small-scale

0.751

High

798791

PRS6B
26S proteasome regulatory subunit 6B

8

10

Small-scale

0.751

High

849291

PSMD7
26S proteasome non-ATPase regulatory subunit 7

8

11

Small-scale

0.751

High

907203

PRS8
26S proteasome regulatory subunit 8

8

12

Small-scale

0.751

High

913378

PRS10
26S proteasome regulatory subunit 10B

8

11

Small-scale

0.751

High

1062909

PSMD6
26S proteasome non-ATPase regulatory subunit 6

8

7

Small-scale

0.751

High

1357546

PSD13
26S proteasome non-ATPase regulatory subunit 13

8

4

Small-scale

0.750

High

906957

PRS4
26S proteasome regulatory subunit 4

8

10

Small-scale

0.749

High

1303969

PSMD1
26S proteasome non-ATPase regulatory subunit 1

7

6

Small-scale

0.749

High

983281

UBE3A
Ubiquitin-protein ligase E3A

7

4

Small-scale

0.747

High

819860

PSMD8
26S proteasome non-ATPase regulatory subunit 8

8

2

Small-scale

0.747

High

276222

PSD10
26S proteasome non-ATPase regulatory subunit 10

7

14

Small-scale

0.746

High

1376989

RUVB2
RuvB-like 2

6

4

Small-scale

0.736

High

1290792

MCRS1
Microspherule protein 1

6

1

Small-scale

0.733

High

1334079

ARP8
Actin-related protein 8

6

14

Small-scale

0.733

High

1334272

ARP5
Actin-related protein 5

6

12

Small-scale

0.733

High

1356868

INO80
Chromatin-remodeling ATPase INO80

6

2

Small-scale

0.733

High

1377050

RUVB1
RuvB-like 1

5

4

Small-scale

0.722

High

1240611

IN80E
INO80 complex subunit E

8

0

Small-scale

0.717

High

656802

PSB5
Proteasome subunit beta type-5

5

17

Small-scale

0.716

High

471678

TFPT
TCF3 fusion partner

7

0

Small-scale

0.715

High

832068

PSB3
Proteasome subunit beta type-3

5

16

Small-scale

0.714

High

637763

PSA2
Proteasome subunit alpha type-2

5

17

Small-scale

0.712

High

893779

PSA6
Proteasome subunit alpha type-6

5

16

Small-scale

0.712

High

656667

PSB6
Proteasome subunit beta type-6

4

17

Small-scale

0.697

High

1307231

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.691

High

594671

PSB1
Proteasome subunit beta type-1

4

20

Small-scale

0.691

High

637620

PSA1
Proteasome subunit alpha type-1

4

14

Small-scale

0.691

High

638055

PSA3
Proteasome subunit alpha type-3

4

15

Small-scale

0.691

High

638224

PSA4
Proteasome subunit alpha type-4

4

15

Small-scale

0.691

High

656348

PSA5
Proteasome subunit alpha type-5

4

13

Small-scale

0.691

High

832188

PSB2
Proteasome subunit beta type-2

4

18

Small-scale

0.691

High

1303503

PSB7
Proteasome subunit beta type-7

4

11

Small-scale

0.691

High

656556

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.683

High

1161702

IN80C
INO80 complex subunit C

4

0

Small-scale

0.670

High

1318778

IN80B
INO80 complex subunit B

4

0

Small-scale

0.670

High

152816

RGPD8
RANBP2-like and GRIP domain-containing protein 8

3

3

High-throughput

0.667

High

1305521

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

3

3

High-throughput

0.667

High

1378078

FHOD1
FH1/FH2 domain-containing protein 1

3

1

High-throughput

0.667

High

1122025

IN80D
INO80 complex subunit D

4

0

Small-scale

0.653

High

156384

PSA7
Proteasome subunit alpha type-7

3

14

Small-scale

0.650

High

870949

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

7

Small-scale

0.643

High

1121467

CCD92
Coiled-coil domain-containing protein 92

3

0

High-throughput

0.638

High

1310363

PAAF1
Proteasomal ATPase-associated factor 1

4

7

High-throughput

0.636

High

989423

PRDX1
Peroxiredoxin-1

2

9

Small-scale

0.624

High

893632

SEM1
26S proteasome complex subunit SEM1

3

0

Small-scale

0.622

High

398154

ISG15
Ubiquitin-like protein ISG15

1

13

Small-scale

0.618

High

1267300

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.618

High

1357351

UBQL1
Ubiquilin-1

1

8

Small-scale

0.618

High

1139479

ECM29
Proteasome adapter and scaffold protein ECM29

2

10

Small-scale

0.611

High

1297543

CC74B
Coiled-coil domain-containing protein 74B

3

1

High-throughput

0.609

High

918214

H4
Histone H4

2

2

Small-scale

0.595

High

950345

SMAD3
Mothers against decapentaplegic homolog 3

2

7

Small-scale

0.595

High

1119688

MIDN
Midnolin

1

0

High-throughput

0.586

High

1061400

PSME4
Proteasome activator complex subunit 4

2

0

Small-scale

0.585

High

1081903

PSMD5
26S proteasome non-ATPase regulatory subunit 5

2

0

Small-scale

0.585

High

245136

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

785429

ELK3
ETS domain-containing protein Elk-3

2

7

Small-scale

0.584

High

1192286

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

4

Small-scale

0.584

High

734445

TCF7
Transcription factor 7

1

2

Small-scale

0.578

High

963712

E2F1
Transcription factor E2F1

1

3

Small-scale

0.578

High

718541

NOS2
Nitric oxide synthase, inducible

2

0

Small-scale

0.576

High

330609

ZBED1
E3 SUMO-protein ligase ZBED1

1

1

High-throughput

0.573

High

167415

SMAD7
Mothers against decapentaplegic homolog 7

1

7

Small-scale

0.561

High

502727

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.561

High

1306934

HAUS7
HAUS augmin-like complex subunit 7

1

0

Small-scale

0.549

High

170744

AXIN1
Axin-1

1

0

Small-scale

0.537

High

396304

ARGI1
Arginase-1

1

0

Small-scale

0.537

High

331622

ACL6A
Actin-like protein 6A

1

13

Small-scale

0.536

High

1085566

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1303896

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

202698

TXNL1
Thioredoxin-like protein 1

1

10

High-throughput

0.515

High

259317

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

6

High-throughput

0.515

High

570615

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

1

High-throughput

0.515

High

314787

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

1039971

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1261201

ZFN2B
AN1-type zinc finger protein 2B

1

0

High-throughput

0.513

High

1266491

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.513

High

427142

CATD
Cathepsin D

1

1

Small-scale

0.512

High

232616

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.508

High

135310

E2F3
Transcription factor E2F3

1

3

Small-scale

0.501

High

175327

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

211700

ACTN4
Alpha-actinin-4

1

4

Small-scale

0.501

High

337041

PNPH
Purine nucleoside phosphorylase

1

2

Small-scale

0.501

High

360581

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

Small-scale

0.501

High

376353

ANXA1
Annexin A1

1

10

Small-scale

0.501

High

396130

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

428657

INVO
Involucrin

1

2

Small-scale

0.501

High

444521

K1C19
Keratin, type I cytoskeletal 19

1

11

Small-scale

0.501

High

451801

ANXA4
Annexin A4

1

10

Small-scale

0.501

High

495645

THIO
Thioredoxin

1

8

Small-scale

0.501

High

531311

EF2
Elongation factor 2

1

2

Small-scale

0.501

High

534007

ANXA8
Annexin A8

1

10

Small-scale

0.501

High

538070

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.501

High

551879

DESP
Desmoplakin

1

13

Small-scale

0.501

High

589259

ANXA7
Annexin A7

1

10

Small-scale

0.501

High

596338

FILA
Filaggrin

1

5

Small-scale

0.501

High

597559

GSTM3
Glutathione S-transferase Mu 3

1

2

Small-scale

0.501

High

618204

COF1
Cofilin-1

1

3

Small-scale

0.501

High

644210

EF1G
Elongation factor 1-gamma

1

4

Small-scale

0.501

High

668068

SPB3
Serpin B3

1

2

Small-scale

0.501

High

670778

PRDX6
Peroxiredoxin-6

1

9

Small-scale

0.501

High

678535

S10A7
Protein S100-A7

1

7

Small-scale

0.501

High

683159

CASPE
Caspase-14

1

1

Small-scale

0.501

High

738825

SPB5
Serpin B5

1

3

Small-scale

0.501

High

845385

RAB7A
Ras-related protein Rab-7a

1

6

Small-scale

0.501

High

857262

CAZA1
F-actin-capping protein subunit alpha-1

1

2

Small-scale

0.501

High

885336

EPIPL
Epiplakin

1

8

Small-scale

0.501

High

888236

TPIS
Triosephosphate isomerase

1

1

Small-scale

0.501

High

892946

IF4A1
Eukaryotic initiation factor 4A-I

1

7

Small-scale

0.501

High

927709

1433Z
14-3-3 protein zeta/delta

1

8

Small-scale

0.501

High

933685

TBA4A
Tubulin alpha-4A chain

1

12

Small-scale

0.501

High

935851

HBB
Hemoglobin subunit beta

1

2

Small-scale

0.501

High

936103

HBA
Hemoglobin subunit alpha

1

2

Small-scale

0.501

High

941621

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

Small-scale

0.501

High

963933

SET
Protein SET

1

3

Small-scale

0.501

High

965227

CAP1
Adenylyl cyclase-associated protein 1

1

2

Small-scale

0.501

High

994037

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

Small-scale

0.501

High

1028459

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.501

High

1045242

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

Small-scale

0.501

High

1046025

PKP1
Plakophilin-1

1

5

Small-scale

0.501

High

1051781

E2F2
Transcription factor E2F2

1

3

Small-scale

0.501

High

1055871

DSC3
Desmocollin-3

1

3

Small-scale

0.501

High

1078708

SMAD2
Mothers against decapentaplegic homolog 2

1

7

Small-scale

0.501

High

1138016

AXA81
Annexin A8-like protein 1

1

10

Small-scale

0.501

High

1154037

K2C80
Keratin, type II cytoskeletal 80

1

7

Small-scale

0.501

High

1189589

K1C28
Keratin, type I cytoskeletal 28

1

10

Small-scale

0.501

High

1189694

K1C26
Keratin, type I cytoskeletal 26

1

13

Small-scale

0.501

High

1205255

K2C73
Keratin, type II cytoskeletal 73

1

9

Small-scale

0.501

High

1231042

K2C78
Keratin, type II cytoskeletal 78

1

10

Small-scale

0.501

High

1245318

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

High-throughput

0.501

High

1264899

RFFL
E3 ubiquitin-protein ligase rififylin

1

2

High-throughput

0.501

High

1269108

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

6

Small-scale

0.501

High

1282081

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.501

High

1291404

S10AG
Protein S100-A16

1

7

Small-scale

0.501

High

1299110

SPB12
Serpin B12

1

2

Small-scale

0.501

High

1301534

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

High-throughput

0.501

High

1303674

K1C12
Keratin, type I cytoskeletal 12

1

11

Small-scale

0.501

High

1306360

THIOM
Thioredoxin, mitochondrial

1

9

Small-scale

0.501

High

1312290

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

7

Small-scale

0.501

High

1317499

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.501

High

1317550

TRI55
Tripartite motif-containing protein 55

1

19

High-throughput

0.501

High

1284414

CC74A
Coiled-coil domain-containing protein 74A

1

1

High-throughput

0.489

High

537150

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.481

High

1317105

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

5

High-throughput

0.481

High

305054

DUS14
Dual specificity protein phosphatase 14

1

0

Small-scale

0.480

High

345158

CYTA
Cystatin-A

1

0

Small-scale

0.480

High

388829

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.480

High

539868

IDE
Insulin-degrading enzyme

1

0

Small-scale

0.480

High

60453

POTEF
POTE ankyrin domain family member F

1

11

Small-scale

0.479

High

126182

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

3

Small-scale

0.479

High

239637

EIF1B
Eukaryotic translation initiation factor 1b

1

2

High-throughput

0.479

High

295463

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

320073

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

High-throughput

0.479

High

327870

CBX7
Chromobox protein homolog 7

1

4

High-throughput

0.479

High

333574

CYB5
Cytochrome b5

1

1

Small-scale

0.479

High

365118

FRIL
Ferritin light chain

1

1

Small-scale

0.479

High

365255

FRIH
Ferritin heavy chain

1

1

Small-scale

0.479

High

375160

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

380532

K2C6B
Keratin, type II cytoskeletal 6B

1

9

Small-scale

0.479

High

380709

K2C1
Keratin, type II cytoskeletal 1

1

9

Small-scale

0.479

High

430402

PROF1
Profilin-1

1

1

Small-scale

0.479

High

450582

RET1
Retinol-binding protein 1

1

2

High-throughput

0.479

High

487876

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

531439

K1C10
Keratin, type I cytoskeletal 10

1

14

Small-scale

0.479

High

570231

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

656147

PSB9
Proteasome subunit beta type-9

1

17

High-throughput

0.479

High

671039

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

9

Small-scale

0.479

High

685803

PRDX2
Peroxiredoxin-2

1

9

Small-scale

0.479

High

717468

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

724155

K1C9
Keratin, type I cytoskeletal 9

1

12

Small-scale

0.479

High

749994

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

800648

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

11

Small-scale

0.479

High

813886

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

875480

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

892141

ACTB
Actin, cytoplasmic 1

1

11

Small-scale

0.479

High

896281

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

899093

PSME3
Proteasome activator complex subunit 3

1

4

Small-scale

0.479

High

930067

ACTG
Actin, cytoplasmic 2

1

11

Small-scale

0.479

High

931956

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

932477

ACTC
Actin, alpha cardiac muscle 1

1

9

Small-scale

0.479

High

942288

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

961341

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

986876

PSME1
Proteasome activator complex subunit 1

1

4

Small-scale

0.479

High

1036250

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1037034

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

1072218

PCBP2
Poly(rC)-binding protein 2

1

7

Small-scale

0.479

High

1072738

UBE3C
Ubiquitin-protein ligase E3C

1

5

Small-scale

0.479

High

1164393

POTEE
POTE ankyrin domain family member E

1

11

Small-scale

0.479

High

1172444

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1189113

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1304914

ELF4
ETS-related transcription factor Elf-4

1

7

High-throughput

0.479

High

1326859

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

1330906

Q9H4D1
Protein kinase

1

7

High-throughput

0.479

High

1355011

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1356777

PSME2
Proteasome activator complex subunit 2

1

4

Small-scale

0.479

High

1357332

PRP19
Pre-mRNA-processing factor 19

1

3

Small-scale

0.479

High

1377849

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

Small-scale

0.479

High

1378079

Q9Y6E3
26S proteasome non-ATPase regulatory subunit 13

1

3

High-throughput

0.479

High

310253

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.458

High

361415

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.458

High

376522

APOB
Apolipoprotein B-100

1

0

Small-scale

0.458

High

532657

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

1204878

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.458

High

1281891

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1282459

PSMG2
Proteasome assembly chaperone 2

1

0

Small-scale

0.458

High

1286771

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1299050

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

Small-scale

0.458

High

1317108

SRXN1
Sulfiredoxin-1

1

0

Small-scale

0.458

High

1329887

PININ
Pinin

1

0

High-throughput

0.458

High

1332824

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

537577

PA2GA
Phospholipase A2, membrane associated

1

2

Small-scale

0.457

High

996025

DSC1
Desmocollin-1

1

2

Small-scale

0.457

High

1336564

S10AE
Protein S100-A14

1

7

Small-scale

0.457

High

789375

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.445

High

883692

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

1342387

RAB18
Ras-related protein Rab-18

1

5

High-throughput

0.445

High

1190465

TRI46
Tripartite motif-containing protein 46

1

18

High-throughput

0.439

High

196904

CYB5B
Cytochrome b5 type B

1

1

Small-scale

0.437

High

385797

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

671550

ECHM
Enoyl-CoA hydratase, mitochondrial

1

2

Small-scale

0.437

High

740984

FDFT
Squalene synthase

1

1

High-throughput

0.437

High

622718

ERD21
ER lumen protein-retaining receptor 1

2

0

High-throughput

0.328

High

134692

NPT3
Sodium-dependent phosphate transport protein 3

1

0

High-throughput

0.279

Low

1128887

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

1074596

CDSN
Corneodesmosin

1

0

Small-scale

0.261

Low

1121828

APRV1
Retroviral-like aspartic protease 1

1

0

Small-scale

0.261

Low

1261839

POF1B
Protein POF1B

1

0

Small-scale

0.261

Low

1166106

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1173057

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024