HitPredict

Interactor 1: ITB1 (P05556)
Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Gene: ITGB1

Interactor 2: ITA5 (P08648)
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Gene: ITGA5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 25237190, 30021884, 20643357, 12883474, 12114318, 7681433, 33961781, 21947080, 22178926, 12724312, 22451694, 16099422
Identification Methods pull down, proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, cross-linking study, enzyme linked immunosorbent assay, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF_2~Integrin_alpha2, I-EGF_1~Integrin_alpha2, Integrin_B_tail~Integrin_alpha2, FG-GAP~Integrin_beta, Integrin_alpha2~Integrin_beta, Integrin_alpha2~PSI_integrin
Common GO terms GO:0001618 - virus receptor activity
GO:0001726 - ruffle
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
and 18 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 798
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Last updated: 15 Jul 2024