HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.818

Property	Details
Experiments	15821101, 11970898
Identification Methods	enzymatic study, phosphatase assay
Interaction Type	direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0060397 - growth hormone receptor signaling pathway via JAK-STAT
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 770
+	Hs
		570489 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		570492 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		573623 PTN1_HUMAN (1-435): 0: 539: 100.00		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		573605 PTN1_HUMAN (1-435): 0: 539: 100.00		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		146922 PTPRT_HUMAN (6-278): 5.46e-63: 222: 26.57		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776659 PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		786664 PTN2_MOUSE (3-432): 2.12e-155: 447: 52.56		STA5B_MOUSE (1-734): 0: 760: 30.59
+	Mm
		786649 PTN2_MOUSE (3-432): 2.12e-155: 447: 52.56		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Mm
		665978 PTN6_MOUSE (193-435): 5.39e-13: 72.7: 11.32		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		665813 PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		786325 PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		570493 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		STAT6_HUMAN (1-753): 0: 627: 24.10
+	Mm
		665977 PTN6_MOUSE (193-435): 5.39e-13: 72.7: 11.32		STAT1_MOUSE (1-749): 0: 914: 51.32
+	Mm
		719288 PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		849884 PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786601 PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		665833 PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		617014 PTPRD_HUMAN (1-278): 8.51e-109: 354: 31.45		Q9BXH2_HUMAN (702-752): 1.16e-16: 76.4: 98.04