HitPredict

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	36279628, 33846359
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	HSP90~Hormone_recep
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 933 Hs			1 724
+	Hs
		442850 PRGR_HUMAN (1-933): 5.59e-132: 421: 100.00		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		467773 MCR_HUMAN (12-933): 2.59e-104: 349: 29.89		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Mm
		443608 GCR_MOUSE (256-933): 1.11e-101: 337: 35.04		HS90B_MOUSE (1-724): 0: 1086: 99.59
+	Mm
		61771 A3KN90_MOUSE (12-933): 6.29e-99: 334: 29.91		HS90B_MOUSE (1-724): 0: 1086: 99.59
+	Hs
		461046 MCR_HUMAN (12-933): 2.59e-104: 349: 29.89		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		403750 GCR_HUMAN (256-933): 7.42e-99: 329: 33.53		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Rn
		443587 GCR_RAT (256-933): 1.36e-96: 323: 34.31		HS90B_RAT (1-724): 0: 1086: 99.59
+	Hs
		467997 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		403743 GCR_HUMAN (256-933): 7.42e-99: 329: 33.53		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		343210 ERR2_HUMAN (483-917): 8.54e-97: 313: 24.37		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461064 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		468322 NR1H3_HUMAN (473-916): 1.46e-95: 310: 20.97		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Rn
		443595 GCR_RAT (256-933): 1.36e-96: 323: 34.31		HS90A_RAT (1-724): 0: 1066: 84.45
+	Hs
		343207 ERR2_HUMAN (483-917): 8.54e-97: 313: 24.37		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461425 NR1H3_HUMAN (473-916): 1.46e-95: 310: 20.97		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461775 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		395339 ESR1_HUMAN (436-917): 2.06e-89: 298: 22.00		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		403790 GCR_HUMAN (256-933): 7.42e-99: 329: 33.53		ENPL_HUMAN (3-693): 0: 914: 46.44
+	Hs
		573602 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		ENPL_HUMAN (3-693): 0: 914: 46.44
+	Hs
		1202025 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		H90B3_HUMAN (1-724): 0: 815: 75.83