HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.50	0.578

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 236
+	Hs
		442763 HCK_HUMAN (1-526): 0: 635: 100.00		NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95
+	Hs
		411635 LCK_HUMAN (23-526): 0: 581: 64.89		NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94
+	Hs
		411684 LCK_HUMAN (23-526): 0: 581: 64.89		NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84
+	Hs
		433503 YES_HUMAN (1-524): 0: 570: 56.77		TEN1_HUMAN (143-233): 6.49e-14: 72.8: 19.30
+	Hs
		433637 LYN_HUMAN (22-526): 0: 554: 70.70		NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94
+	Hs
		433715 LYN_HUMAN (22-526): 0: 554: 70.70		NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84
+	Dm
		246709 ABL_DROME (5-519): 3.97e-167: 515: 38.10		TENM_DROME (2-124): 1.24e-14: 74.7: 17.71
+	Hs
		337391 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94
+	Hs
		337591 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		NOTC3_HUMAN (12-198): 1.58e-11: 65.5: 29.67