HitPredict

Interactor 1: PDC1 (P06169)
Pyruvate decarboxylase isozyme 1 (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
Gene: PDC1

Interactor 2: PDC1 (P06169)
Pyruvate decarboxylase isozyme 1 (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
Gene: PDC1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.851

The method score is based on:

Property Details
Experiments 29557065, 8512926, 10651824, 19246454
Identification Methods affinity chromatography technology, x-ray crystallography
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains TPP_enzyme_C~TPP_enzyme_C, TPP_enzyme_C~TPP_enzyme_M, TPP_enzyme_C~TPP_enzyme_N, TPP_enzyme_M~TPP_enzyme_M, TPP_enzyme_M~TPP_enzyme_N, TPP_enzyme_N~TPP_enzyme_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0000949 - aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
GO:0004737 - pyruvate decarboxylase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 10 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 563
Sc

1 563
+ Sc
+ Sc
+ Sc
+ Sc
+ Nc
+ Sp
+ Ec
+ At
+ Ec
+ Sc
+ Sc
+ Hs
+ Sc
+ Ec
+ Zm
+ Ec

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Last updated: 15 Jul 2024