HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: LIPA1 (Q13136)
Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)
Gene: PPFIA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0030424 - axon GO:0032991 - protein-containing complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1202
+	Hs
		541461 FGFR1_HUMAN (195-794): 0: 544: 26.34		LIPA1_HUMAN (1-1202): 1.11e-166: 528: 100.00
+	Hs
		1095537 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		LIPA1_HUMAN (1-1202): 1.11e-166: 528: 100.00
+	Hs
		648496 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		LIPA1_HUMAN (1-1202): 1.11e-166: 528: 100.00
+	Hs
		1095605 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPA1_HUMAN (1-1202): 1.11e-166: 528: 100.00
+	Hs
		711883 LTK_HUMAN (502-790): 3.11e-60: 221: 41.64		LIPA1_HUMAN (1-1202): 1.11e-166: 528: 100.00
+	Hs
		411475 NTRK1_HUMAN (1-796): 0: 624: 100.00		MYH10_HUMAN (44-609): 2.55e-18: 93.5: 15.52
+	Hs
		411474 NTRK1_HUMAN (1-796): 0: 624: 100.00		MYH9_HUMAN (300-869): 4.94e-13: 76.4: 11.41
+	Hs
		412199 NTRK1_HUMAN (1-796): 0: 624: 100.00		LIPB1_HUMAN (277-521): 3.39e-12: 73.2: 15.51
+	Hs
		412274 NTRK1_HUMAN (1-796): 0: 624: 100.00		LIPB2_HUMAN (175-407): 4.04e-09: 63.2: 12.88
+	Hs
		541571 FGFR1_HUMAN (195-794): 0: 544: 26.34		LIPB1_HUMAN (277-521): 3.39e-12: 73.2: 15.51
+	Hs
		1159510 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		LIPB1_HUMAN (277-521): 3.39e-12: 73.2: 15.51
+	Hs
		648573 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		LIPB1_HUMAN (277-521): 3.39e-12: 73.2: 15.51
+	Hs
		710604 EPHA3_HUMAN (262-788): 6.31e-112: 365: 26.64		MYH9_HUMAN (300-869): 4.94e-13: 76.4: 11.41
+	Hs
		773304 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		MYH10_HUMAN (44-609): 2.55e-18: 93.5: 15.52
+	Hs
		773080 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		MYH9_HUMAN (300-869): 4.94e-13: 76.4: 11.41
+	Hs
		1292207 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPB1_HUMAN (277-521): 3.39e-12: 73.2: 15.51
+	Hs
		1336249 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPB2_HUMAN (175-407): 4.04e-09: 63.2: 12.88