HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: LIPB2 (Q8ND30)
Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)
Gene: PPFIBP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SAM_1
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 876
+	Hs
		412199 NTRK1_HUMAN (1-796): 0: 624: 100.00		LIPB1_HUMAN (1-875): 2.14e-95: 323: 40.66
+	Hs
		541571 FGFR1_HUMAN (195-794): 0: 544: 26.34		LIPB1_HUMAN (1-875): 2.14e-95: 323: 40.66
+	Hs
		1159510 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		LIPB1_HUMAN (1-875): 2.14e-95: 323: 40.66
+	Hs
		648573 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		LIPB1_HUMAN (1-875): 2.14e-95: 323: 40.66
+	Hs
		412120 NTRK1_HUMAN (1-796): 0: 624: 100.00		SARM1_HUMAN (174-713): 1.43e-51: 195: 14.37
+	Hs
		648612 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		ANS1A_HUMAN (273-850): 2.97e-56: 212: 16.33
+	Hs
		1336249 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPB2_HUMAN (1-876): 5.97e-160: 491: 100.00
+	Hs
		412892 NTRK1_HUMAN (1-796): 0: 624: 100.00		MRCKB_HUMAN (119-372): 2.08e-09: 63.8: 14.04
+	Hs
		411847 NTRK1_HUMAN (1-796): 0: 624: 100.00		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87
+	Hs
		541461 FGFR1_HUMAN (195-794): 0: 544: 26.34		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87
+	Hs
		1095537 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87
+	Hs
		648496 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87
+	Hs
		1292207 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPB1_HUMAN (1-875): 2.14e-95: 323: 40.66
+	Hs
		1366050 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		ANS1A_HUMAN (273-850): 2.97e-56: 212: 16.33
+	Hs
		1095605 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87
+	Hs
		711883 LTK_HUMAN (502-790): 3.11e-60: 221: 41.64		LIPA1_HUMAN (12-442): 3.25e-09: 63.1: 12.87