HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3
Common GO terms	GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 372
+	Hs
		235231 FYN_HUMAN (1-537): 0: 643: 100.00		NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31
+	Hs
		442875 HCK_HUMAN (1-535): 0: 548: 56.64		CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87
+	Mm
		411919 LCK_MOUSE (40-535): 0: 553: 57.20		CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37
+	Hs
		433961 LYN_HUMAN (1-535): 0: 535: 54.48		CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87
+	Mm
		435879 HCK_MOUSE (1-535): 0: 542: 56.45		CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37
+	Hs
		235232 YES_HUMAN (1-537): 0: 591: 71.61		NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31
+	Hs
		337354 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00
+	Hs
		412016 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRD_HUMAN (58-341): 1.32e-15: 80.7: 10.10
+	Mm
		56907 FYN_MOUSE (1-537): 0: 642: 99.44		PTPRF_MOUSE (70-341): 7.24e-13: 72.2: 9.19
+	Hs
		411959 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRF_HUMAN (70-341): 2.76e-11: 67.2: 8.83
+	Hs
		522808 SRC_HUMAN (1-537): 0: 598: 68.21		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Hs
		560468 TEC_HUMAN (5-529): 6.12e-163: 478: 34.89		PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68
+	Hs
		411613 LCK_HUMAN (40-535): 0: 551: 57.60		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Hs
		411565 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRF_HUMAN (70-341): 2.76e-11: 67.2: 8.83
+	Hs
		442787 HCK_HUMAN (1-535): 0: 548: 56.64		IL6RB_HUMAN (55-302): 3e-12: 70.2: 14.17
+	Hs
		433804 LYN_HUMAN (1-535): 0: 535: 54.48		SDK2_HUMAN (23-206): 6.47e-10: 63: 13.76
+	Hs
		674354 ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Mm
		70553 B2RQ57_MOUSE (7-537): 3.15e-168: 506: 37.71		UFO_MOUSE (4-342): 1.19e-12: 71.4: 16.18