HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	11739737
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 586
+	Hs
		523086 SRC_HUMAN (1-537): 0: 598: 68.21		GAB3_HUMAN (1-586): 1.2e-108: 339: 100.00
+	Hs
		523213 SRC_HUMAN (1-537): 0: 598: 68.21		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Mm
		403466 SRC_MOUSE (1-537): 0: 599: 68.33		GAB1_MOUSE (1-585): 1.34e-51: 190: 27.44
+	Hs
		411861 LCK_HUMAN (40-535): 0: 551: 57.60		PKHA5_HUMAN (4-580): 9.83e-67: 237: 12.52
+	Hs
		522965 SRC_HUMAN (1-537): 0: 598: 68.21		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		166024 FYN_HUMAN (1-537): 0: 643: 100.00		SYNJ2_HUMAN (138-572): 8.44e-34: 139: 9.11
+	Hs
		433345 YES_HUMAN (1-537): 0: 591: 71.61		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		433388 YES_HUMAN (1-537): 0: 591: 71.61		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Mm
		639464 LYN_MOUSE (1-535): 0: 535: 53.92		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Hs
		411709 LCK_HUMAN (40-535): 0: 551: 57.60		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		442825 HCK_HUMAN (1-535): 0: 548: 56.64		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		411764 LCK_HUMAN (40-535): 0: 551: 57.60		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		433750 LYN_HUMAN (1-535): 0: 535: 54.48		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		411897 LCK_HUMAN (40-535): 0: 551: 57.60		PKHA6_HUMAN (4-458): 2.39e-36: 147: 13.21
+	Hs
		522749 SRC_HUMAN (1-537): 0: 598: 68.21		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		297808 LYN_HUMAN (1-535): 0: 535: 54.48		K0754_HUMAN (100-573): 5.03e-30: 128: 11.04
+	Hs
		411582 LCK_HUMAN (40-535): 0: 551: 57.60		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		203198 LCK_HUMAN (40-535): 0: 551: 57.60		SYNJ1_HUMAN (110-572): 1.24e-12: 73.3: 9.79
+	Hs
		433560 LYN_HUMAN (1-535): 0: 535: 54.48		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		411772 LCK_HUMAN (40-535): 0: 551: 57.60		MPRIP_HUMAN (8-301): 3.32e-10: 65.2: 13.38