HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	15169881, 23346089
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 370
+	Hs
		523136 SRC_HUMAN (1-537): 0: 598: 68.21		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Mm
		763408 FYN_MOUSE (1-537): 0: 642: 99.44		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		412176 FYN_HUMAN (1-537): 0: 643: 100.00		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		411939 FYN_HUMAN (1-537): 0: 643: 100.00		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		523015 SRC_HUMAN (1-537): 0: 598: 68.21		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		433317 YES_HUMAN (1-537): 0: 591: 71.61		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		454828 FGR_HUMAN (1-536): 0: 581: 69.82		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		411818 LCK_HUMAN (40-535): 0: 551: 57.60		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		789096 ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Hs
		411561 LCK_HUMAN (40-535): 0: 551: 57.60		CD48_HUMAN (28-247): 2.6e-46: 160: 22.42
+	Hs
		411547 LCK_HUMAN (40-535): 0: 551: 57.60		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		433691 LYN_HUMAN (1-535): 0: 535: 54.48		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		416917 ITK_HUMAN (4-526): 5.88e-165: 483: 31.90		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		433742 LYN_HUMAN (1-535): 0: 535: 54.48		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Dm
		219802 ABL_DROME (4-537): 3.97e-166: 513: 38.01		O44924_DROME (135-312): 8.74e-13: 71.9: 8.65