Protein: SH2B2
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)

Gene: SH2B2
Organism: Homo sapiens
Interactions: 40
UniProt ID: O14492

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0001726 - ruffle
GO:0001922 - B-1 B cell homeostasis
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154413

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.800

High

154416

HCK
Tyrosine-protein kinase HCK

2

19

High-throughput

0.783

High

154440

PKHA3
Pleckstrin homology domain-containing family A member 3

2

15

High-throughput

0.783

High

154442

RAB6B
Ras-related protein Rab-6B

2

15

High-throughput

0.783

High

154443

ASB6
Ankyrin repeat and SOCS box protein 6

2

15

High-throughput

0.783

High

154412

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

154435

WDR83
WD repeat domain-containing protein 83

3

1

High-throughput

0.770

High

154425

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

154414

INSR
Insulin receptor

2

20

Small-scale

0.757

High

154409

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.755

High

154436

SRBS1
Sorbin and SH3 domain-containing protein 1

2

20

Small-scale

0.754

High

154433

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

154420

CBL
E3 ubiquitin-protein ligase CBL

5

20

Small-scale

0.723

High

154441

SH2B1
SH2B adapter protein 1

1

19

Small-scale

0.713

High

154423

CLK1
Dual specificity protein kinase CLK1

2

14

High-throughput

0.700

High

154424

CLK3
Dual specificity protein kinase CLK3

2

14

High-throughput

0.700

High

154415

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

154417

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.691

High

154411

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

154419

EPOR
Erythropoietin receptor

1

20

Small-scale

0.647

High

154421

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.647

High

154427

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

154407

SH2B2
SH2B adapter protein 2

1

18

Small-scale

0.621

High

154408

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.618

High

154422

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

154410

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

16

High-throughput

0.606

High

154430

LMO3
LIM domain only protein 3

2

20

High-throughput

0.606

High

154437

TLRN1
Talin rod domain-containing protein 1

2

1

High-throughput

0.606

High

154444

I36RA
Interleukin-36 receptor antagonist protein

2

3

High-throughput

0.606

High

154445

DS13B
Dual specificity protein phosphatase 13B

2

11

High-throughput

0.606

High

154426

TLE5
TLE family member 5

2

3

High-throughput

0.553

High

154429

F90A1
Protein FAM90A1

2

1

High-throughput

0.553

High

154431

ZN417
Zinc finger protein 417

2

7

High-throughput

0.553

High

154438

MAGH1
Melanoma-associated antigen H1

2

5

High-throughput

0.553

High

154439

F124B
Protein FAM124B

2

1

High-throughput

0.553

High

154418

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

15

High-throughput

0.536

High

154428

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

154432

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

154434

ZN414
Zinc finger protein 414

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025