Protein: SHC4
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)

Gene: SHC4
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q6S5L8

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0010468 - regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363441

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.952

High

1247473

SHC3
SHC-transforming protein 3

2

19

High-throughput

0.789

High

987714

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

472082

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532088

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1038446

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.692

High

410907

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

641615

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

1145743

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

412119

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

1053687

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.618

High

1159507

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1247472

NBEA
Neurobeachin

2

4

High-throughput

0.611

High

1247475

GARE1
GRB2-associated and regulator of MAPK protein 1

2

6

High-throughput

0.611

High

177894

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

20

High-throughput

0.558

High

607698

DCAM
S-adenosylmethionine decarboxylase proenzyme

2

3

High-throughput

0.558

High

520146

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1247474

NUAK2
NUAK family SNF1-like kinase 2

1

2

High-throughput

0.536

High

463989

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.527

High

651364

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

1137788

TNIP1
TNFAIP3-interacting protein 1

1

17

High-throughput

0.437

High


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Last updated: 11Aug2025