HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 34079125
Identification Methods	pull down, proximity labelling technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 694
+	Hs
		442825 HCK_HUMAN (1-509): 0: 602: 65.04		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		522965 SRC_HUMAN (20-507): 0: 586: 55.00		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		433750 LYN_HUMAN (1-509): 0: 582: 62.72		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		433345 YES_HUMAN (26-507): 0: 581: 58.06		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		403466 SRC_MOUSE (28-507): 0: 583: 57.05		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		846468 BLK_HUMAN (1-509): 0: 557: 59.35		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		523213 SRC_HUMAN (20-507): 0: 586: 55.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		434086 LYN_HUMAN (1-509): 0: 582: 62.72		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		639464 LYN_MOUSE (1-509): 0: 585: 62.33		GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33
+	Hs
		411764 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		412280 FYN_HUMAN (30-507): 0: 586: 59.01		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		523086 SRC_HUMAN (20-507): 0: 586: 55.00		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		433922 LYN_HUMAN (1-509): 0: 582: 62.72		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		411861 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		411897 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33
+	Hs
		433831 LYN_HUMAN (1-509): 0: 582: 62.72		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		433388 YES_HUMAN (26-507): 0: 581: 58.06		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		434015 LYN_HUMAN (1-509): 0: 582: 62.72		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		434016 LYN_HUMAN (1-509): 0: 582: 62.72		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (339-656): 1.08e-09: 64.4: 11.22