HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1504
+	Hs
		541769 FGFR1_HUMAN (195-794): 0: 544: 26.34		NISCH_HUMAN (1-1504): 0: 1784: 100.00
+	Hs
		1159558 NTRK2_HUMAN (12-796): 1.39e-176: 529: 47.08		NISCH_HUMAN (1-1504): 0: 1784: 100.00
+	Hs
		1157120 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		NISCH_HUMAN (1-1504): 0: 1784: 100.00
+	Hs
		648748 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		NISCH_HUMAN (1-1504): 0: 1784: 100.00
+	Hs
		412245 NTRK1_HUMAN (1-796): 0: 624: 100.00		S11IP_HUMAN (129-547): 1.15e-54: 211: 23.24
+	Hs
		412217 NTRK1_HUMAN (1-796): 0: 624: 100.00		CEP97_HUMAN (221-554): 1.06e-54: 209: 25.85
+	Hs
		412531 NTRK1_HUMAN (1-796): 0: 624: 100.00		LRRC1_HUMAN (217-563): 6.42e-45: 173: 20.49
+	Hs
		412212 NTRK1_HUMAN (1-796): 0: 624: 100.00		LRC49_HUMAN (190-554): 8.26e-40: 161: 21.47
+	Hs
		412627 NTRK1_HUMAN (1-796): 0: 624: 100.00		LRC40_HUMAN (64-390): 2.4e-22: 105: 17.00
+	Hs
		412221 NTRK1_HUMAN (1-796): 0: 624: 100.00		LRC8A_HUMAN (209-418): 2.2e-21: 103: 21.82
+	Hs
		411913 NTRK1_HUMAN (1-796): 0: 624: 100.00		SCRIB_HUMAN (209-577): 1.61e-17: 91.3: 18.01
+	Hs
		411840 NTRK1_HUMAN (1-796): 0: 624: 100.00		FLII_HUMAN (25-297): 1.32e-10: 68.6: 11.64
+	Hs
		541482 FGFR1_HUMAN (195-794): 0: 544: 26.34		SCRIB_HUMAN (209-577): 1.61e-17: 91.3: 18.01
+	At
		88664 TMK1_ARATH (62-786): 8.12e-146: 454: 20.34		GSO1_ARATH (1-301): 5.88e-44: 177: 12.90
+	Hs
		1122241 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		SCRIB_HUMAN (209-577): 1.61e-17: 91.3: 18.01
+	Hs
		648509 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		SCRIB_HUMAN (209-577): 1.61e-17: 91.3: 18.01
+	Mm
		581999 NTRK2_MOUSE (12-796): 1.1e-175: 527: 48.05		LRRC7_MOUSE (34-280): 7.85e-09: 62.8: 9.56
+	At
		265868 TMK1_ARATH (62-786): 8.12e-146: 454: 20.34		BAME3_ARATH (1-156): 1.28e-14: 81.7: 6.21
+	Mm
		1281869 PTK7_MOUSE (201-781): 2.35e-146: 458: 27.17		LRRC7_MOUSE (34-280): 7.85e-09: 62.8: 9.56
+	At
		235804 TMK1_ARATH (62-786): 8.12e-146: 454: 20.34		BAME1_ARATH (481-664): 2.82e-09: 63.9: 10.45