Protein: LRC49
Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4)

Gene: LRC49, LRRC49
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q8IUZ0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005874 - microtubule
GO:0034451 - centriolar satellite

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143398

PCM1
Pericentriolar material 1 protein

5

3

High-throughput

0.712

High

351282

TTLL1
Polyglutamylase complex subunit TTLL1

4

1

High-throughput

0.691

High

412212

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.675

High

1308100

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

4

0

High-throughput

0.661

High

1228228

TPGS2
Tubulin polyglutamylase complex subunit 2

3

0

High-throughput

0.634

High

1256392

TPGS1
Tubulin polyglutamylase complex subunit 1

3

0

High-throughput

0.634

High

1308097

NICN1
Nicolin-1

3

0

High-throughput

0.634

High

131466

EIF3F
Eukaryotic translation initiation factor 3 subunit F

4

5

High-throughput

0.630

High

343407

SNP29
Synaptosomal-associated protein 29

2

1

High-throughput

0.601

High

1149318

STIL
SCL-interrupting locus protein

2

1

High-throughput

0.584

High

1248149

SAS6
Spindle assembly abnormal protein 6 homolog

2

9

High-throughput

0.584

High

1308089

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

1

High-throughput

0.574

High

878502

PAXI
Paxillin

1

4

High-throughput

0.553

High

1049168

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.553

High

1226161

CP135
Centrosomal protein of 135 kDa

2

7

High-throughput

0.533

High

369065

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

725516

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

0

High-throughput

0.513

High

135650

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.479

High

177015

CE290
Centrosomal protein of 290 kDa

1

10

High-throughput

0.479

High

242198

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

245336

CE104
Centrosomal protein of 104 kDa

1

1

High-throughput

0.479

High

245492

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

3

High-throughput

0.479

High

299273

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

436928

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.479

High

437257

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

548350

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

891660

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.479

High

984186

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

1063399

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.479

High

1104212

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

1

High-throughput

0.479

High

1109868

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1151767

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1177960

MOONR
Protein moonraker

1

1

High-throughput

0.479

High

1193438

CCD14
Coiled-coil domain-containing protein 14

1

1

High-throughput

0.479

High

1203185

ODFP2
Outer dense fiber protein 2

1

9

High-throughput

0.479

High

1215471

CE162
Centrosomal protein of 162 kDa

1

14

High-throughput

0.479

High

1258293

MOB2
MOB kinase activator 2

1

3

High-throughput

0.479

High

1295477

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

High-throughput

0.479

High

1308088

CE120
Centrosomal protein of 120 kDa

1

8

High-throughput

0.479

High

1308094

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.479

High

1308095

CK5P2
CDK5 regulatory subunit-associated protein 2

1

13

High-throughput

0.479

High

1308101

MOB1A
MOB kinase activator 1A

1

3

High-throughput

0.479

High

1308102

CPAP
Centrosomal P4.1-associated protein

1

7

High-throughput

0.479

High

1308104

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1308109

MYO6
Unconventional myosin-VI

1

5

High-throughput

0.479

High

1308111

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

1308112

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.479

High

1308114

PHOCN
MOB-like protein phocein

1

3

High-throughput

0.479

High

281614

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

552628

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

827835

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.458

High

941200

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

1308084

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

1308096

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1308107

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

477241

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.457

High

1308110

CP131
Centrosomal protein of 131 kDa

1

7

High-throughput

0.445

High

76554

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

8

High-throughput

0.437

High

124398

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

164000

NDC80
Kinetochore protein NDC80 homolog

1

11

High-throughput

0.437

High

317880

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.437

High

341100

DIRA3
GTP-binding protein Di-Ras3

1

11

High-throughput

0.437

High

439774

INSR
Insulin receptor

1

20

High-throughput

0.437

High

451408

NFM
Neurofilament medium polypeptide

1

11

High-throughput

0.437

High

572941

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.437

High

621493

HXK1
Hexokinase-1

1

1

High-throughput

0.437

High

621681

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

698849

CALX
Calnexin

1

6

High-throughput

0.437

High

702009

TMOD1
Tropomodulin-1

1

1

High-throughput

0.437

High

710350

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.437

High

710638

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.437

High

710726

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.437

High

764384

CTNA1
Catenin alpha-1

1

3

High-throughput

0.437

High

956373

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.437

High

1034282

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.437

High

1125525

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

4

High-throughput

0.437

High

1141756

EEA1
Early endosome antigen 1

1

10

High-throughput

0.437

High

1233322

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1235294

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.437

High

1241677

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.437

High

1256506

CE128
Centrosomal protein of 128 kDa

1

14

High-throughput

0.437

High

1308083

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.437

High

1308085

CNTRB
Centrobin

1

11

High-throughput

0.437

High

1308086

AHI1
Jouberin

1

8

High-throughput

0.437

High

1308091

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.437

High

1308092

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.437

High

1308093

PF21A
PHD finger protein 21A

1

7

High-throughput

0.437

High

1308108

RCOR1
REST corepressor 1

1

1

High-throughput

0.437

High

255109

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

848792

MAGAA
Melanoma-associated antigen 10

1

2

High-throughput

0.407

High

1308113

SGT1
Protein SGT1 homolog

1

13

High-throughput

0.407

High

1237856

SANBR
SANT and BTB domain regulator of class switch recombination

3

0

High-throughput

0.345

High

1308087

TBC19
TBC1 domain family member 19

2

0

High-throughput

0.328

High

686713

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1219189

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

246736

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

291422

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

326583

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

880601

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1293608

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1308090

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.249

Low

1308098

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.249

Low

1308099

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

1308103

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.249

Low

1308105

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

1308106

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1308115

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025