HitPredict - High confidence protein-protein interactions

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	15937332, 17277083, 24909783
Identification Methods	x-ray crystallography, cosedimentation in solution, molecular sieving
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001223 - transcription coactivator binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific and 31 others more... GO:0001542 - ovulation from ovarian follicle GO:0002071 - glandular epithelial cell maturation GO:0003677 - DNA binding GO:0003707 - nuclear steroid receptor activity GO:0004879 - nuclear receptor activity GO:0004930 - G protein-coupled receptor activity GO:0005102 - signaling receptor binding GO:0005496 - steroid binding GO:0005654 - nucleoplasm GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0007165 - signal transduction GO:0007267 - cell-cell signaling GO:0008270 - zinc ion binding GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0019899 - enzyme binding GO:0030518 - nuclear receptor-mediated steroid hormone signaling pathway GO:0034056 - estrogen response element binding GO:0038001 - paracrine signaling GO:0042326 - negative regulation of phosphorylation GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048286 - lung alveolus development GO:0050678 - regulation of epithelial cell proliferation GO:0050847 - progesterone receptor signaling pathway GO:0051117 - ATPase binding GO:0051457 - maintenance of protein location in nucleus GO:0060748 - tertiary branching involved in mammary gland duct morphogenesis
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	933
Hs

1	933

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Last updated: 15 Jul 2024