HitPredict

Interactor 1: HSP16 (P06581)
Heat shock protein Hsp-16.41
Gene: hsp-16.41

Interactor 2: HSP12 (P06582)
Heat shock protein hsp-16.2
Gene: hsp-16.2

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.723

Property	Details
Experiments	19123269
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0009408 - response to heat GO:0036498 - IRE1-mediated unfolded protein response GO:0042026 - protein refolding and 1 others more... GO:0051082 - unfolded protein binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 143 Ce			1 145
+	Ce
		415556 HSP16_CAEEL (1-143): 2.85e-51: 161: 100.00		HSP11_CAEEL (1-145): 8.37e-54: 167: 93.10
+	Hs
		358696 CRYAA_HUMAN (6-142): 6.36e-44: 143: 26.80		CRYAA_HUMAN (2-144): 5.56e-38: 128: 25.79
+	Hs
		358699 CRYAA_HUMAN (6-142): 6.36e-44: 143: 26.80		HSPB1_HUMAN (14-145): 3.31e-37: 127: 26.06
+	Ce
		1176673 Q7JP52_CAEEL (7-142): 2.16e-41: 136: 29.29		Q7JP52_CAEEL (4-138): 2.63e-39: 131: 29.71
+	Hs
		358697 CRYAA_HUMAN (6-142): 6.36e-44: 143: 26.80		CRYAB_HUMAN (4-144): 5.19e-36: 123: 29.30
+	Hs
		358941 CRYAA_HUMAN (6-142): 6.36e-44: 143: 26.80		V9HW27_HUMAN (4-144): 5.19e-36: 123: 29.30
+	Bt
		358695 CRYAA_BOVIN (6-142): 2.17e-42: 139: 27.45		CRYAB_BOVIN (4-144): 1.18e-36: 125: 30.57
+	Hs
		388144 HSPB1_HUMAN (4-142): 4.61e-41: 137: 27.06		HSPB1_HUMAN (14-145): 3.31e-37: 127: 26.06
+	Ce
		1093852 Q20660_CAEEL (3-142): 6.36e-41: 135: 29.25		Q20660_CAEEL (4-138): 2.68e-38: 128: 30.22
+	Hs
		358950 HSPB1_HUMAN (4-142): 4.61e-41: 137: 27.06		CRYAB_HUMAN (4-144): 5.19e-36: 123: 29.30
+	Rn
		621311 CRYAB_RAT (7-142): 1.86e-40: 135: 30.00		HSPB1_RAT (25-137): 1.58e-36: 125: 31.30
+	Hs
		358767 CRYAA_HUMAN (6-142): 6.36e-44: 143: 26.80		HSPB2_HUMAN (27-133): 1.73e-30: 109: 29.63
+	Hs
		388788 HSPB1_HUMAN (4-142): 4.61e-41: 137: 27.06		HSPB8_HUMAN (9-128): 1.9e-31: 112: 26.23
+	Hs
		388468 HSPB1_HUMAN (4-142): 4.61e-41: 137: 27.06		HSPB2_HUMAN (27-133): 1.73e-30: 109: 29.63
+	At
		580280 HS178_ARATH (1-140): 7.24e-41: 135: 18.83		HS181_ARATH (1-139): 1.03e-30: 109: 19.26
+	Hs
		147844 HSPB1_HUMAN (4-142): 4.61e-41: 137: 27.06		HSPB6_HUMAN (23-119): 4.41e-29: 105: 30.69