HitPredict

Interactor 1: S10A8 (P05109)
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)
Gene: S100A8

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37249651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0045087 - innate immune response
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 93 Hs			1 475
+	Hs
		623418 HORN_HUMAN (2-89): 4.3e-30: 113: 25.00		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		623137 S10AB_HUMAN (2-93): 2.51e-32: 109: 26.04		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		444897 S10A9_HUMAN (2-88): 1.26e-28: 101: 26.09		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		623373 FILA2_HUMAN (2-89): 2.16e-25: 99: 29.35		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		623552 S10AE_HUMAN (3-80): 1.43e-21: 82.6: 20.25		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		623094 FILA_HUMAN (2-90): 3.73e-19: 82.2: 27.96		RO52_HUMAN (1-475): 7.68e-175: 500: 100.00
+	Hs
		706258 S10A2_HUMAN (1-92): 5.23e-30: 103: 27.08		TRI11_HUMAN (1-473): 6.52e-143: 419: 42.53
+	Hs
		445236 S10A6_HUMAN (1-88): 1.68e-27: 97.2: 24.44		TRI11_HUMAN (1-473): 6.52e-143: 419: 42.53
+	Hs
		1295714 HORN_HUMAN (2-89): 4.3e-30: 113: 25.00		TRIM6_HUMAN (1-466): 4.04e-131: 390: 43.73