HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.759

Property	Details
Experiments	26196320, 1540595, 36109631, 26342197, 20048054, 27903893, 25500540, 32206096, 1525041, 17974989, 35785414, 19706771, 21157430, 19805354, 17353003
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 920
+	Hs
		437831 HS90B_HUMAN (19-732): 0: 1059: 86.13		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		368832 HS90A_HUMAN (1-732): 0: 1087: 100.00		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		368839 HS90B_HUMAN (19-732): 0: 1059: 86.13		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		377015 HS90A_HUMAN (1-732): 0: 1087: 100.00		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Gg
		430819 HS90B_CHICK (1-732): 0: 1072: 84.04		PRGR_CHICK (260-920): 9.23e-122: 390: 36.58
+	Hs
		432122 HS90A_HUMAN (1-732): 0: 1087: 100.00		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Rn
		415141 HS90A_RAT (1-732): 0: 1085: 97.95		GCR_RAT (444-920): 1.59e-112: 365: 40.04
+	Hs
		431441 HS90A_HUMAN (1-732): 0: 1087: 100.00		MCR_HUMAN (401-920): 3.98e-106: 353: 38.18
+	Hs
		414416 HS90A_HUMAN (1-732): 0: 1087: 100.00		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		320155 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERR2_HUMAN (467-904): 1.64e-111: 351: 22.73
+	Hs
		377022 HS90B_HUMAN (19-732): 0: 1059: 86.13		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Mm
		415154 HS90B_MOUSE (19-732): 0: 1063: 86.98		GCR_MOUSE (444-920): 1.46e-113: 368: 40.24
+	Rn
		415133 HS90B_RAT (19-732): 0: 1063: 86.98		GCR_RAT (444-920): 1.59e-112: 365: 40.04
+	Mm
		59437 HS90B_MOUSE (19-732): 0: 1063: 86.98		A3KN90_MOUSE (90-920): 4.3e-106: 353: 29.58
+	Hs
		437625 HS90B_HUMAN (19-732): 0: 1059: 86.13		MCR_HUMAN (401-920): 3.98e-106: 353: 38.18
+	Hs
		414418 HS90B_HUMAN (19-732): 0: 1059: 86.13		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		320158 HS90B_HUMAN (19-732): 0: 1059: 86.13		ERR2_HUMAN (467-904): 1.64e-111: 351: 22.73
+	Hs
		437901 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71
+	Hs
		431801 HS90A_HUMAN (1-732): 0: 1087: 100.00		NR1H3_HUMAN (492-903): 9.35e-96: 310: 22.27
+	Hs
		438124 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR1H3_HUMAN (492-903): 9.35e-96: 310: 22.27