HitPredict

Interactor 1: PGFRB (P05622)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: Pdgfrb

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	8264620
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:2000379 - positive regulation of reactive oxygen species metabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1098 Mm			1 217
+	Hs
		484098 PGFRB_HUMAN (1-1098): 0: 789: 85.35		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Hs
		593330 PGFRA_HUMAN (4-1098): 0: 706: 42.73		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Mm
		431951 PGFRB_MOUSE (1-1098): 0: 848: 100.00		FYN_MOUSE (161-215): 1.26e-13: 70.8: 31.58
+	Hs
		484041 PGFRB_HUMAN (1-1098): 0: 789: 85.35		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		362131 PGFRB_HUMAN (1-1098): 0: 789: 85.35		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		484076 PGFRB_HUMAN (1-1098): 0: 789: 85.35		ABL2_HUMAN (4-139): 9.74e-22: 94.7: 34.04
+	Hs
		484038 PGFRB_HUMAN (1-1098): 0: 789: 85.35		VAV_HUMAN (3-60): 1.48e-15: 76.5: 43.10
+	Hs
		440307 PGFRB_HUMAN (1-1098): 0: 789: 85.35		FYN_HUMAN (161-215): 1.22e-13: 71.1: 31.58
+	Hs
		484240 PGFRB_HUMAN (1-1098): 0: 789: 85.35		VAV3_HUMAN (3-57): 6.01e-13: 69: 38.18
+	Hs
		462952 PGFRB_HUMAN (1-1098): 0: 789: 85.35		YES_HUMAN (161-215): 4.3e-12: 66.5: 28.07
+	Hs
		484033 PGFRB_HUMAN (1-1098): 0: 789: 85.35		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Hs
		484084 PGFRB_HUMAN (1-1098): 0: 789: 85.35		VAV2_HUMAN (3-56): 6.05e-11: 63.1: 38.18
+	Rn
		634980 PGFRA_RAT (4-1098): 0: 696: 42.82		LYN_RAT (135-215): 2.82e-10: 61.1: 25.30
+	Hs
		439920 KIT_HUMAN (23-1002): 0: 604: 31.14		LCK_HUMAN (3-202): 4.02e-36: 134: 27.49
+	Hs
		362136 KIT_HUMAN (23-1002): 0: 604: 31.14		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Mm
		483860 CSF1R_MOUSE (10-968): 0: 606: 33.30		FYN_MOUSE (161-215): 1.26e-13: 70.8: 31.58
+	Hs
		440316 KIT_HUMAN (23-1002): 0: 604: 31.14		FYN_HUMAN (161-215): 1.22e-13: 71.1: 31.58
+	Mm
		431316 CSF1R_MOUSE (10-968): 0: 606: 33.30		SRC_MOUSE (75-215): 6.13e-12: 66.1: 17.48
+	Mm
		313428 CSF1R_MOUSE (10-968): 0: 606: 33.30		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Hs
		292803 KIT_HUMAN (23-1002): 0: 604: 31.14		GRAP2_HUMAN (3-55): 7.11e-11: 62.5: 39.62