HitPredict

Interactor 1: TNR16 (P08138)
Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
Gene: NGFR

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30081046
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007411 - axon guidance GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 282
+	Hs
		129526 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		436620 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		436641 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF4_HUMAN (25-151): 5.73e-26: 107: 20.00
+	Hs
		584394 TNR1A_HUMAN (29-417): 1.27e-76: 247: 18.27		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		591320 TNR1B_HUMAN (8-274): 1.53e-45: 165: 18.32		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Mm
		192584 TNR11_MOUSE (13-211): 1.29e-41: 157: 24.02		TRAF5_MOUSE (25-148): 8.8e-26: 108: 21.05
+	Hs
		129532 TNR5_HUMAN (13-254): 4.68e-42: 151: 22.14		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		129607 TNR11_HUMAN (22-210): 6.26e-39: 150: 24.35		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Mm
		936208 TNR14_MOUSE (12-207): 3.6e-42: 151: 25.62		TRAF5_MOUSE (25-148): 8.8e-26: 108: 21.05
+	Hs
		639578 TNR5_HUMAN (13-254): 4.68e-42: 151: 22.14		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		639638 TNR5_HUMAN (13-254): 4.68e-42: 151: 22.14		TRAF4_HUMAN (25-151): 5.73e-26: 107: 20.00
+	Hs
		1024798 TNR11_HUMAN (22-210): 6.26e-39: 150: 24.35		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		129536 TNR3_HUMAN (23-316): 3.68e-33: 131: 14.92		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		129584 TNR14_HUMAN (12-184): 1.31e-34: 131: 27.22		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		1024725 TNR14_HUMAN (12-184): 1.31e-34: 131: 27.22		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		738661 TNR3_HUMAN (23-316): 3.68e-33: 131: 14.92		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		738694 TNR3_HUMAN (23-316): 3.68e-33: 131: 14.92		TRAF4_HUMAN (25-151): 5.73e-26: 107: 20.00
+	Hs
		632265 TNR6_HUMAN (26-148): 1.61e-33: 130: 24.81		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		129538 TNR4_HUMAN (32-247): 5.47e-32: 124: 26.24		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		738713 TNR3_HUMAN (23-316): 3.68e-33: 131: 14.92		RN114_HUMAN (22-123): 6.82e-18: 82.1: 26.85