HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SERPH (P50454)
Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)
Gene: SERPINH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.578

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Serpin~fn3
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 418
+	Rn
		431479 INSR_RAT (1-1382): 0: 1513: 94.29		SPA3K_RAT (5-409): 3.05e-165: 472: 23.97
+	Hs
		465461 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		895677 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		411591 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		411467 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		SPB6_HUMAN (43-409): 3.2e-151: 435: 29.52
+	Hs
		895565 NTRK3_HUMAN (996-1290): 1.94e-64: 238: 39.43		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		895544 MERTK_HUMAN (835-1301): 1.61e-62: 234: 32.36		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		650090 FGFR3_HUMAN (1015-1287): 2.22e-62: 231: 40.78		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00
+	Hs
		410511 ERBB2_HUMAN (32-343): 3.5e-21: 102: 20.74		PAI1_HUMAN (13-409): 3.55e-144: 418: 23.76
+	Hs
		477217 ROS1_HUMAN (722-946): 5.64e-13: 76.3: 15.93		SERPH_HUMAN (1-418): 2.86e-152: 439: 100.00