Protein: PAI1
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)

Gene: PAI1, SERPINE1
Organism: Homo sapiens
Interactions: 59
UniProt ID: P05121

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366458

UROK
Urokinase-type plasminogen activator

5

20

Small-scale

0.922

High

399523

VTNC
Vitronectin

3

2

Small-scale

0.834

High

366515

TPA
Tissue-type plasminogen activator

2

20

Small-scale

0.778

High

366083

THRB
Prothrombin

1

20

Small-scale

0.647

High

366311

PLMN
Plasminogen

1

20

Small-scale

0.647

High

226667

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

4

High-throughput

0.616

High

424605

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

3

5

High-throughput

0.616

High

389641

A1AG1
Alpha-1-acid glycoprotein 1

2

2

Small-scale

0.606

High

424611

UBQL2
Ubiquilin-2

2

7

High-throughput

0.606

High

424578

CFTR
Cystic fibrosis transmembrane conductance regulator

2

7

High-throughput

0.601

High

424597

SMAD4
Mothers against decapentaplegic homolog 4

3

3

Small-scale

0.593

High

424596

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

Small-scale

0.586

High

424593

SMAD3
Mothers against decapentaplegic homolog 3

2

3

Small-scale

0.584

High

424606

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

424573

PAI1
Plasminogen activator inhibitor 1

1

9

Small-scale

0.575

High

424574

GDN
Glia-derived nexin

1

11

High-throughput

0.575

High

424601

FBLN7
Fibulin-7

1

1

High-throughput

0.575

High

424612

UBQL1
Ubiquilin-1

1

7

High-throughput

0.573

High

224925

TLX3
T-cell leukemia homeobox protein 3

2

1

High-throughput

0.553

High

424592

PITX1
Pituitary homeobox 1

2

3

High-throughput

0.553

High

424602

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

424579

ENPL
Endoplasmin

1

4

High-throughput

0.536

High

424575

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

424576

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.513

High

424598

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.513

High

424609

UBQL4
Ubiquilin-4

1

8

High-throughput

0.494

High

424585

ERP29
Endoplasmic reticulum resident protein 29

1

3

High-throughput

0.489

High

424588

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

2

High-throughput

0.489

High

177645

SMAD7
Mothers against decapentaplegic homolog 7

1

3

Small-scale

0.479

High

217709

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

400105

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

410511

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.479

High

424580

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.479

High

424581

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

424583

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

424587

BASI
Basigin

1

2

High-throughput

0.479

High

424594

VIGLN
Vigilin

1

3

High-throughput

0.479

High

424610

FBLN5
Fibulin-5

1

3

Small-scale

0.479

High

424582

IBP5
Insulin-like growth factor-binding protein 5

1

0

Small-scale

0.458

High

424584

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.458

High

424586

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

424590

MFAP2
Microfibrillar-associated protein 2

1

0

Small-scale

0.458

High

424599

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

73759

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

4

High-throughput

0.445

High

351646

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.445

High

424577

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

4

High-throughput

0.445

High

424600

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.445

High

424604

CA054
Uncharacterized protein C1orf54

1

1

High-throughput

0.445

High

424607

ANTR1
Anthrax toxin receptor 1

1

3

High-throughput

0.445

High

385360

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

370911

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

424589

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.437

High

424591

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

424595

OTUD4
OTU domain-containing protein 4

1

1

Small-scale

0.437

High

424608

ANLN
Anillin

1

2

High-throughput

0.437

High

170614

CLGN
Calmegin

1

2

High-throughput

0.407

High

424603

DHB11
Estradiol 17-beta-dehydrogenase 11

2

0

High-throughput

0.316

High

344062

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025