HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10871282
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 676
+	Hs
		441499 MET_HUMAN (1-1390): 0: 1283: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		555049 MET_MOUSE (1-1381): 0: 1246: 89.57		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Mm
		101608 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		981867 RON_HUMAN (23-1390): 0: 934: 32.70		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		872436 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		872642 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665596 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		674415 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		435634 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		872492 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		872712 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		872491 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		665662 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		1072603 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		665661 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		1072602 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		674531 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		435768 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		411498 INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		435765 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35