HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: NGEF (Q8N5V2)
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Gene: NGEF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.767

The method score is based on:

Property Details
Experiments 25814554, unassigned1126
Identification Methods two hybrid, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, PH~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005829 - cytosol
GO:0030154 - cell differentiation
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 526
Hs

1 710
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024