HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	22641034, 20670214
Identification Methods	two hybrid, pull down, nuclear magnetic resonance, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 868
+	Hs
		523081 SRC_HUMAN (1-524): 0: 582: 54.51		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		433429 YES_HUMAN (1-524): 0: 570: 56.77		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		412278 FYN_HUMAN (22-524): 0: 564: 57.79		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Mm
		403468 SRC_MOUSE (1-524): 0: 585: 55.56		PDC6I_MOUSE (1-868): 0: 638: 94.25
+	Hs
		523149 SRC_HUMAN (1-524): 0: 582: 54.51		PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93
+	Hs
		111443 J3QRU1_HUMAN (1-524): 0: 570: 56.77		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		433272 YES_HUMAN (1-524): 0: 570: 56.77		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		412058 FYN_HUMAN (22-524): 0: 564: 57.79		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		523231 SRC_HUMAN (1-524): 0: 582: 54.51		MYH4_HUMAN (137-704): 3.04e-51: 197: 11.80
+	Hs
		433620 LYN_HUMAN (22-526): 0: 554: 70.70		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		724720 BLK_HUMAN (22-526): 0: 540: 63.12		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Mm
		70886 SRC_MOUSE (1-524): 0: 585: 55.56		EP300_MOUSE (527-864): 1.99e-35: 148: 13.58
+	Hs
		522942 SRC_HUMAN (1-524): 0: 582: 54.51		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		411694 LCK_HUMAN (23-526): 0: 581: 64.89		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		996554 ITK_HUMAN (3-517): 1.06e-168: 492: 33.21		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		297808 LYN_HUMAN (22-526): 0: 554: 70.70		K0754_HUMAN (709-860): 1.45e-11: 70.7: 23.42